文档介绍：该【神经营养素信号通路 】是由【业精于勤】上传分享，文档一共【19】页，该文档可以免费在线阅读，需要了解更多关于【神经营养素信号通路 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。NeurotrophinSignaling (TrkSignalingPathway)*神经营养素信号通路*–NervegrowthfactorBDNF–Brain-derivedneurotrophicfactorNT3–Neurotrophin3NT4–Neurotrophin4*神经营养素信号通路*FunctionAclassofgrowthfactors,secretedproteinsthatarecapableofsignalingparticularcellstosurvive,(PCD)-,*神经营养素信号通路**神经营养素信号通路*BiogenesisTheneurotrophinsareinitiallysynthesizedasprecursorsorpro-neurotrophins,whicharecleavedtoproducethematureproteins.(ProNGF->NGF)Pro-neurotrophinsarecleavedintracellularlybyFURINorpro-convertasesatahighlyconserveddibasicamino-acidcleavagesitetoreleasecarboxy-:about12kDainsize,formstable,non-covalentdimers,-terminalhalf(orpro-domain)ofthepro-neurotrophinisbelievedtobeimportantfortheproperfoldingandintracellularsortingofneurotrophins.*神经营养素信号通路*NeurotrophinReceptorsEachneurotrophincansignalthroughtwodifferenttypesofcellsurfacereceptorTrkreceptortyrosinekinasesp75neurotrophinreceptor(p75NTR).Transmembranereceptor,(TNFR)death-receptorfamily.*神经营养素信号通路*,inreality,thebindingofNGFtoTrkA,andofBDNFtoTrkBisoflowaffinity,butitcanberegulatedbyreceptordimerization,*神经营养素信号通路*Thep75receptorcanbindtoeachneurotrophin,andalsoactsasaco-,*神经营养素信号通路*plexbetweenTrkAandp75SecondarystructureSymmetry*神经营养素信号通路*ModelsofTrkandp75receptorTrkreceptorscontainextracellularimmunoglobulinG(IgG)-richrepeats,,*神经营养素信号通路*