文档介绍：该【《转基因治病模型》 】是由【相惜】上传分享，文档一共【40】页，该文档可以免费在线阅读，需要了解更多关于【《转基因治病模型》 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。TransgenicMutationAnimalAssays 转基因动物致突变模型TaoChen,,博士NationalCenterforToxicologicalResearch,,?什么是突变?MutationsareheritablechangesinthenucleotidesequenceofDNAellscancauseneoplasmsandpossiblyagingicdiseases,includingbirthdefectsandcancerMutationandCancer突变和癌症MutationisnotequaltocancerCancer:ellmutationsMutationasabiomarkerofcancer 突变可用作癌症的生物指标Mutationassaysasshort-termtestsforcarcinogenicityInvitro::Hprtassay,Aprtassay,TkassayandtransgenicassayInvivoevidenceismoreimportantthaninvitroevidenceTransgenicmutationsystems 转基因致突变系统Transgenicanimalsformutationassays 检测突变的转基因动物Transgenicanimalsareanimalswhosecellscontainforeigntargetgenes(reportergenes)reportergenesarenormallylocatedonshuttlevectorsthatarederivativesofbacteriophageorplasmidsThevectorsrecoverthemutationaltargetfromrodentsformutantdetectioninbacteriaShuttlevector穿梭载体Ashuttlevectorcontainingreportergene(s)→JcoscIIQRPRTransgenicrodentmutationmodels 转基因动物突变模型