文档介绍：临床肺科杂志 2014年4月第19卷第4期 597 布地奈德合剂防治RDS早期疗效研究刘东成陆妹劳庆禄李卫东何源李源斌【摘要】目的探讨气管内滴人不同布地奈德合剂联合经鼻持续气道正压(NCPAP)对呼吸窘迫综合征(RDS)的早期疗效差异。方法按纳入标准随机将RDS高危早产儿91例(预防RDS28例,诊断RDS治疗63 例)分为观察组()和对照组(气管内滴人固尔苏一布地奈德混合剂),均予 NCPAP通气,比较预防病例RDS发生率和RDS治疗病例PaO:/FiO2改善情况。结果两组均无RDS新发病例;两组RDS病例治疗前及治疗后6、12hPaO/FiO无差异(P>),治疗后1小时观察组比对照组低(P <)。结论两种布地奈德混合剂及早气管内滴人均能有效预防RDS、改善RDS肺功能,但观察组显效慢。【关键词】布地奈德;肺表面活性物质;沐舒坦;PaO:/FiO;呼吸窘迫综合征 ClinicalstudyofbudesonideinthepreventionofRDSLIUDong—cheng,LUMei,LAOQing—lu,LIWei—d0,, HEYuan,LIYuan—binXiaolanAffiliatedHospitalofSouthernMedwalUniversity,Zhongshan,Guangdong528415 China 【Abstract】ObjectiveToexploretheearlycurativeeffectdifferenceofearlyintratrachealinstillationof binedwithnasalcontinuouspositiveairwaypressure(NCPAP)onRDS. Methods91preterminfantsofhighriskinRDSwererandomlydividedintotwogroups(including28infantsfor preventingRDSand63infantsofRDS).Theobservationgroupwasgivenintratrachealinstillationofamixtureof high—dosemucosolvanandbudesonideearlyafterbirth,andthecontrolgroupwasgivenintratrachealinstillationofa mixtureofpulmonarysurfactant(PS)— , thetwogroupshad130newRDScases,wjtllnosignificantdifferences(P>).Therewasnosignificantdiffer— enceinPaO2/FiO2betweenthetwogroups(P>)beforeand6and12hoursafter