文档介绍：Bachert et al. World Allergy Organization Journal 2014, 7:25
journal
CONSENSUS DOCUMENT Open Access
ICON: chronic rhinosinusitis
Claus Bachert1*†, Ruby Pawankar2†, Luo Zhang3, Chaweewan Bunnag4, Wytske J Fokkens5, Daniel L Hamilos6,
Orathai Jirapongsananuruk4, Robert Kern7, Eli O Meltzer8, Joaquim Mullol9, Robert Naclerio10, Renata Pilan11,
Chae-Seo Rhee12, Harumi Suzaki13, Richard Voegels14 and Michael Blaiss15
Abstract
Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the
complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to
different disease variants - further complicates our understanding and directions for the most appropriate targeted
treatment strategies. Several International/national guidelines/position papers and/or consensus documents are
available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to
the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the
International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI,
ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose
of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in
recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this
document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes
and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and
treatment options in both adults and children comprising