文档介绍：2
2 2
2
2
2
2 2
2
2
2
2 2
2
2
1 1
1
· 652 · 1 国外医学卫生学分册2 2 2 2007 年第 34 卷第 4 期
[2] INSTITUTE OF MEDICINE , NATIONAL ACADEMY OF Choline ,an essential nutrient for humans [J ]. FASEB J ,
SCIENCES. Dietary reference intakes for folate ,thiamin , 1991 ,5 :2093 2098.
riboflavin , niacin , vitamin B12 , panthothenic acid , biotin , [10] DA COSTA K A , GAFFNEY C E , FISCHER L M ,et al.
and choline [ M ]. Washington , DC: National Academy Choline deficiency in mice and humans is associated with
Press ,1998. increased plasma homocysteine concentration after a
[3] CHENG W L ,HOLMES MCNARYM Q ,MAR M H ,et al. methionine load[J ]. Am J Clin Nutr ,2005 ,81 :440 444.
Bioavailability of choline and choline esters from milk in rat [11] FISHER M C ,ZEISEL S H ,MAR M H ,et al. Inhibitors of
pups[J ]. J Nutr Biochem ,1996 ,7 :457 464. choline uptake and metabolism cause developmental
[4] FISCHER L M , SCEARCE J A , MAR M H , et al. Ad abnormalities in neurulating mouse embryos [J ]. Teratol ,
libitum choline intake in healthy individuals meets or 2001 ,64 : 114 122.
exceeds the proposed adequate intake level [J ]. J Nutr , [12] FISHER M C , ZEISEL S H , MAR M H , et al.
2005 ,135 :826 829. Perturbations in choline metabolism cause neural tube
[5] MELENOVSKY V ,STULC T , KOZICH V ,et al. Effect of defects in mouse embryos in vitro[J ]. FASEBJ ,2002