同步放化疗治疗中晚期宫颈癌.doc

文档介绍：同步放化疗治疗中晚期宫颈癌
作者:刘少兵,周祖金,陈森,覃瑞萍
【摘要】目的观察化疗联合放疗治疗中晚期宫颈癌的临床疗效和毒副作用。方法 58例中晚期宫颈癌患者随机分成化放组(29例)及单纯放疗组(29例),化放组采用顺铂25mg/m2 d13,静脉点滴,5Fu 350mg/m2 d15静脉点滴,每4周重复,共3个周期,同时进行根治性放疗,化疗第1天开始进行放射治疗。用10MVX线体外全盆照射DT38~40Gy,中间铅挡后照射致宫旁剂量DT50~55Gy,第3周开始行192Ir腔内照射,6Gy/次/天/周,A点剂量6Gy,B点剂量5Gy,共6~7次。单纯放射治疗组仅行单纯放疗,方法同化放组,不行化疗。%%,差异无显著(P>)。%%,差异显著(P<)。放化组3、%、%、%,%、%、%,差异显著(P<),随访5年,%,%,P<。化放组有较明显的骨髓抑制和消化道反应,但患者经治疗后均可耐受。结论化疗联合放疗治疗中晚期宫颈癌可增强疗效,副作用稍增加,但患者能耐受。
【关键词】宫颈癌;同步放化疗;疗效;副作用
Prospective Trial for Concurrent Chemoradiotherapy Treatment in Mediumterm and Advanced Cervical Carcinoma
Abstract:Objective To investigate the clinical curative effects and side effects of chemoradiotherapy for mediumterm and advanced cervical carcinoma. Methods FiftyEight patients of mediumterm and advanced cervical carcinoma ly divided into toradiotherapy groups and only radiotherapy group. Each patients of the chemoradiotherapy group g/m2 ivgtt d13 ,5Fluorouracil,350mg/m2 ivgtt,d15, repeat every 28 days, total 3 cycles. And radiotherapy e time, 10 MVX ray iddle field is shielded by plumbum, continuous radiotherapy to total dose of 50~55 Gy; 192Ir highdoserate after loading unit e for total 6~7 times. The patients of radiotherapy group e dose and same methods. Results The eff