文档介绍：光纤传感在线监测格列齐特缓释片的释放度
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光纤传感在线监测格列齐特缓释片的释
放度
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【摘要】目的利用六通道光纤药物溶出度测定仪,建立一种光纤实时在线监测格列齐特缓释片体外释放度的方法。方法分别采用FODT601型光纤药物溶出度实时监测仪和2005年版中国药典的紫外分光光度法在226 nm波长处测定格列齐特缓释片的释放度。%~%,2种测定方法之间差异无显著性()。格列齐特缓释片的释药曲线可用Peppas方程拟合,释药机制为非Fickian扩散。结论光纤药物溶出度过程监测法能有效地测定缓释制剂的体外释放度,并能真实地反映药物释放的全过程,可替代繁琐的传统方法。
【关键词】光纤传感;药物溶出度;实时监测仪;释放度;格列齐特缓释片 Abstract:Objective To establish an online analysis method for the release rate of glicalzide sustainedrelease tablets by six channels fiberoptical chemical sensor dissolution test (FOCSDT) system.
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Methods The drug dissolution concentration was detected respectively using the FOCSDT system and UV (CHP 2005) in 226 nm respectively. Results The recoveries of glicalzide was %~%,and the parameters obtained
by FOCSDT had no significant pared with UV (). The curve of drug release was fitted with the Peppas equation,and the release mechanism of the glicalzide sustainedrelease tablets was unfickian diffusion. Conclusion As an online analysis,real information about the release of drug can be obtained effectively by FOCSDT system,which can take the place of trivial convential methods.
Key words:fiberoptical sensor; drug dissolution;online monitor; release rate; glicalzide sustainedrelease tablets
格列齐特(glicalzide)是第2代口服磺酰脲类降血糖药,可选择性作用于胰岛β细胞