文档介绍：FOLFOX 方案在进展期胃癌新辅助化疗中的应用
李国帅张成武*(青海大学附属医院胃肠外科810001;* 通讯作者,张成武,主任医师)
【摘要】胃癌是我国最常见的恶性肿瘤之一,早期发现较为困难。据统计,我国住院胃癌患者中,进展期占70%~80%[1],而且多伴有淋巴结转移,手术仍然为其首选的治疗方式。此类患者手术切除率低,获得根治性切除的比例较少,5年生存率低,治疗效果差。积极提高手术切除率成为改善胃癌患者预后的一大目标。对于进展期胃癌术前行辅助化疗有助于手术以及提高术后存活率、降低复发及转移率。临床上对于进展期胃癌术前新辅助化疗的方案多种多样,但最常见的仍为FOLFOX方案(奥沙利铂+亚叶酸钙+氟尿嘧啶)。该方案用于进展期胃癌新辅助化疗有效率较高,不良反应多为轻度,经对症处理后可缓解,未影响后续治疗的进行和造成不可逆性损伤,能够增加肿瘤完全切除的机会,提高手术效果[2]。
【关键词】进展期胃癌;新辅助化疗;氟尿嘧啶;亚叶酸钙;奥沙利铂【中图分类号】R2 【文献标号】A 【文章编号】1671-8725(2014)11-0112-02
Application of FOLFOX neoadjuvant chemotherapy regimen inthe treatment of advanced gastric carcinomaLi Guoshuai;Zhang Chengwu(Gastrointestinal surgery of Affiliated Hospital of Qinghai University 810001; * corresponding author, Zhang Chengwu, chief physician)abstract:Objective: Gastric cancer is one of the mon malignant tumor in our country,it's difficult to make detection in patientswith gastric cancer in China,the development period is about 70% to 80% ,and more associated with lymph node metastasis, surgery is still the firstchoice of treatment. Patients with surgical resection rate is low, to obtain the proportion of less radical excision, 5-year survival rate is low, the treatmenteffect is improve the resection rate e a big goal of improving the prognosis of patients with gastric advanced gastric cancerline
preoperative adjuvant chemotherapy helps to i