文档介绍：不同治疗方案在难治性肾病综合征治疗中的效果比较
李文丽陈咏梅陈丽萍
(深圳市福田区第二人民医院广东深圳518049)
摘要:目的研究对难治性肾病患者的治疗方法,探究不同的治疗方案对这些患者的疗效,在比较后为难治性肾病综合征患者提供有效的治疗方案。方法对我院2010年2月至2013年2月收治的40例患者进行研究,并将这些患者随即平均分为A、B两组,A组患者采用盐酸氮芥进行治疗,而B组患者采用环磷酰***进行治疗,在治疗后,对比患者的治疗有效率、不良反应率、TNF-&alpha;水平和血清水平。结果在对40例患者进行治疗后可发现,B组患者的疗效明显好于A组患者,且B组患者出现不良反应率低于A组,IL-6和TNF-&alpha;水平也较A组低,血清IL-2较A组患者高,相关数据进行比较,差异有统计学意义(P<)。结论对难治性肾病综合征的患者进行治疗时采用环磷酰***,效果更好,且比盐酸氮芥更安全,是值得临床推广的治疗方案。
关键词:难治性肾病综合征;不同的治疗方案;效果
Abstract:Purpose Methods of treatment of refractory nephrotic patients, explore the effect of different treatment for these Study of 40 patients in our hospital from 2010 February to 2013 February were, and these patients were randomly divided into A, B two group, the level of TNF- &alpha; and serum level Can be found in the treatment of 40 cases of patients after treatment, patients in the B group was significantly better in the A group patients,the serum IL-2 in patients with A group, compared the relevant data, the difference was statistically significant (P &lt; ).Conclusion Treatment of patients with refractory nephrotic syndrome with cyclophosphamide, the effect is better, and the ratio of nitrogen mustard hydrochloride more security, is worthy of clinical treatment.
Keywords: refractory nephrotic syndrome; the different treatment plan; effect
难治性肾病综合征,也称RNS,属于原发性的肾病综合征,是综合征中FR(复发频繁)、SR(耐药性)和SD(激素依赖