文档介绍：Archs oral Biol. Vol. 42, No. 12, pp. 869-876, 1997
Pergamon © 1997 Elsevier Science Ltd. All rights reserved
Printed in Great Britain
PII: S0003-9969(97)00005-8 0003-9969/97 $ +
EFFECTS OF CAPSAICIN IN TEMPOROMANDIBULAR
JOINT ARTHRITIS IN RATS
J. CARLESON, ''2'4* P. KOGNER, 3 I. BILEVICIUTE, l E. THEODORSSON, 5
A. APPELGREN/ B. APPELGREN, ~'2 S. KOPP, 2 N. YOUSEF 1'2 and
T. LUNDEBERG 1'4
*Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, 2Center for
Clinical Oral Science, School of Dentistry, Karolinska Institutet, S-141 04 Huddinge, 3Department of
Clinical Chemistry, 4Department of Surgery and Rehabilitation, Karolinska Hospital, S-171 76
Stockholm and SDepartment of Clinical Chemistry, University Hospital, S-582 30 Link6ping, Sweden
Summary--Teraporomandibular joint (TMJ) arthritis was induced in female Lewis rats by unilateral
injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the TMJ. Control
rats received paraffin oil by the same route. Arthritic and control rats were pretreated either with cap-
saicin or denervation of the mandibular branch of the trigeminal nerve. Tissues were collected for
neuropeptide extraction and analysed by radioimmunoassay and reverse-phase high-performance liquid
chromatograpky. In all groups, the levels of subst