文档介绍：胸腔内注入顺铂联合白介素-Ⅱ治疗恶性胸腔积液疗效对比
李毅星( 南阳市第二人民医院肿瘤科河南南阳 4 7 3 0 1 2 )
【摘要】目的探讨胸腔内注入顺铂(DD P)联合白介素Ⅱ(I L--Ⅱ)治疗恶性胸腔积液的疗效-。方法病理确诊的恶性胸腔积液60例,经胸腔插管引流术排尽胸液后,按随机化原则分为2组,治疗组(32例)在胸腔内注入DDP50 mg/m2, IL--Ⅱ80万IU,对照组(28例)在胸腔内注入DDP 50 mg/m2,1周后重复1次,观察疗效、生活质量、生存率以及毒副反应。结果治疗组总有效率81%,病变进展率3%,较对照组50%,25%差异有显著性(P<0•05)。Karnofsky评分大于70分治疗组较对照组有显著提高(P<0•05)。治疗组0•5年、1年、1•5年、2年的生存率为97%、59%、44%、6%,分别高于对照组的71%、50%、14%、4%,其中0•5,1•5年的生存率差异有显著性(P<0•05)。治疗组Ⅰ度白细胞下降较对照组明显。结论胸腔内联合注入DDP和IL--Ⅱ治疗恶性胸腔积液是一种有效的、副反应小、可耐受的方法。
【关键词】顺铂白介素-Ⅱ恶性胸腔积液
【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752(2012)01-0379-02
Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection(observation of 60 cases) LI Yixing. Department Oncology Nanyang Second People's Hospital.
【Abstract】Objective To evaluate the efficacy of treating malignant pleural effusion with cisplatine and IL--Ⅱ by injection through thoracic tube 60 cases with
malignant pleural effusion,after drainage, IL--Ⅱ80万IU,cisplatine 50 mg/m2were injectred into pleural cavity in therapy group(T),and only cisplatine 50 mg/m2in control group (C)•thetretment was repeated after a week,then evaluate the efficacy,survival rate,toxicities and quality of
The response rate was 81% in T group and 50% in C group•There
was statistical difference in two groups (P<0•05)&bul