文档介绍：血栓栓塞与同型半胱氨酸的研究进展
王水英(综述) 熊辉霞(审校)(通讯作者)
(青海大学附属医院血液科青海西宁 810001)
【摘要】血栓栓塞是临床上常见的疾病,目前提出同型半胱氨酸(homocysteine HCY)水平的升高与其相关,但其导致该病发生的机制尚不完全清楚。血管内皮损伤,平滑肌细胞增殖,增加血小板活性,炎症反应及改变凝血功能等途径均发挥重要作用。笔者就HCY致血栓栓塞的发病机制的研究进展进行综述,从而更好地指导临床预防和减少血栓栓塞的发生。
【关键词】血栓;栓塞;同型半胱氨酸;发病机制
【中图分类号】R543 【文献标识码】A 【文章编号】2095-1752(2016)22-0017-01
The research progress of thromboembolism and homocysteine WangShuiying,XiongHuixia (communication).
Qinghai University Affiliated Hospital, Qinghai Province, Xining 810001, China
【Abstract】Thromboembolism is mon clinical disease. The rise of homocysteine (HCY) levels associated with it, but the mechanism of factors cause the disease is not fully clear. Vascular endothelial damage, smooth muscle cell proliferation, increase the platelet activity, inflammation, and change the blood coagulation function, etc., all play an important role. This paper reviews the research progress of HCY leads to the pathogenesis of thromboembolism, in order to prevent and reduce the occurrence of thromboembolism better guidance..
【Key words】Thrombosis; Embolism; Homocysteine; The pathogenesis of
血栓栓塞形成的主要因素:血管内皮损伤、血流状态改变和血液高凝,三者往往同时存在。其类型主要为静脉血栓栓塞(VTE)[1]。
多项研究表明,高同型半胱氨酸血症(hyperhomocysteinemia HHCY)是VTE形成的独立危险因素之一[2],但其导致该病发生的机制仍不清楚[3]。HCY来自饮食中的甲硫氨酸,是甲硫氨酸去***形成的含硫氨基酸[4]。
HCY的代谢
HCY在细胞内主要有三种代谢途经,即再***化、转硫化和直接释放到细胞外液。其存在形式:血浆中HCY有l%以游离态存在,80~90%以二硫键与蛋白结合,其余形成同型半