文档介绍：Simulation of ic Fields in a Microelectrode Array
By Barbara Oakley, Julie de Hagen, Darrin Hanna, Basim Al-Khateeb, Mahmoud Al-Nsour
School of Engineering puter Science, Oakland University, Rochester MI USA
Abstract - An area of significant potential in Micro- electrical discharges, demonstrates a long-term bactericidal
Electro-Mechanical Systems (MEMS)-related technology property.[5])
is the construction of microelectrode arrays that can be The answer to these and other questions lie at the heart
used to preferentially kill nearby biological cells while of any research in the proposed area. In this brief synopsis,
leaving cells more distant from the array intact. This we begin to address the question of optimal microelectrode
paper details some of the basic considerations related to geometry (question 3 above) through simulations of electric
this research area, and goes on to explore fields using Field Precision's Mesh3W, Pac3_W, and
ic field strength and its spatial variation VPac3.[6]
around a simple simulated microelectrode array near a
biological medium with σ and ε characteristics similar II. SIMULATIONS
to that of human blood. Simulations were conducted at
maximum field strengths of | | volts at a frequency of A very simple microelectrode geometry (Fig. 1) is
100 kHz and 1 MHz. effective in producing relatively large volumes of high
electric field