罗格列酮对重症急性胰腺炎的保护作用.doc

文档介绍：罗格列***对重症急性胰腺炎的保护作用
:蔡笃雄,曾仕平,汤净,林尤冠
【摘要】目的:探讨罗格列***对重症急性胰腺炎(SAP)的保护作用及其作用机制。方法:72只健康SD大鼠随机分为3组:假手术组(SO组)、SAP组及罗格列***处理组。采用经十二指肠胰胆管逆行注射5%牛磺胆酸钠诱导大鼠SAP模型,于模型制作前30min腹腔内注射罗格列***(10mg/kg)进行预处理,各组于术后3h、6h和12h分批处死动物,观察各组大鼠血浆淀粉酶、TNFα、IL6、胰腺组织髓过氧化物酶(MPO)水平的变化以及胰腺组织病理改变,并进行病理学评分。结果:SAP组血浆淀粉酶、TNFα、IL6、胰腺组织MPO、胰腺组织病理学评分较SO组均明显升高(P<),罗格列***处理组各时间点血浆淀粉酶、TNFα、IL6、胰腺组织MPO水平均较SAP组显著降低(P<),6h、12h胰腺组织病理评分均显著低于SAP组(P<),各时间点胰腺组织病理损伤较SAP组明显减轻。结论:罗格列***可能通过减少TNFα、IL6的产生,减轻胰腺组织损伤,从而改善SAP病情。
【关键词】急性胰腺炎;罗格列***;细胞因子
[ABSTRACT] Objective: To investigate the protective effect and mechanism of rosiglitazone on severe acute pancreatitis (SAP). Methods: Seventytized into three groups: sham operation (SO)group, SAP group and rosiglitazone pretreated group. The model of SAP taurocholate into the bilipancreatic duct in SD rats, rosiglitazone pretreated group g/kg rosiglitazone intraperitoneally 30 min before inducing SAP. Rats in the three groups odel. The levels of amylase, TNFα, IL6 in plasm myeloperoxidase (MPO) of pancreas easured. The histopathological changes and the histologic scores of pancreatic tissue amylase,TNFα, IL6, the intrapancreatic MPO significantly increased in SAP group(P<), and the histologic scores of pancreatic tissue significantly decreased in SAP group(P<), and the pancreas injury amylase, TNFα, IL6 ,intrapancreatic MPO significan