文档介绍：Materials and Design 31 (2010) 3463–3473
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Materials and Design
journal homepage: ate/matdes
Design-optimization and material selection for a femoral-fracture
fixation-plate implant
M. Grujicic a,*, G. Arakere a, X. Xie a, M. LaBerge b, A. Grujicic b, . Wagner c, A. Vallejo c
a Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, United States
b Department of Bioengineering, Clemson University, Clemson, SC 29634, United States
c Ozen Engineering, Inc., 1210 E. Arques Avenue, Suite: 207, Sunnyvale, CA 94085, United States
article info abstract
Article history: The problem of size/thickness optimization of a distal femoral-fracture fixation-plate is -
Received 17 July 2009 putationally using bined finite-element/design-optimization procedure. To obtain realistic physio-
Accepted 20 January 2010 logical loading conditions associated with normal living activities (cycling, in the present case), a
Available online 25 January 2010
musculoskeletal multi-body inverse-dynamics analysis is carried out of a human riding the bicycle. While
optimizing the design of the femoral-fracture locking-plate, realistic functional requirements pertaining
Keywords: to attain the required level of fracture-femur fixation and longevity/lifecycle were used. It is argued that
Musculoskeletal modeling and simulations
these types of analysis should be used plement pre-clinical implant-evaluation tests, the tests
Femoral-fracture fixed-plate implant
which normally include a limited number of physiological loading conditions and single pass/fail out-
Optimization
comes/decisions with respect to a set of lower-bound implant–performance criteria.
Ó 2010 Elsevier Ltd. All rights reserved.
1. Introduction (including the material selected for the implant) are optimal (with
respect to their size, weight, cost, etc.).
Significant advantages are associated with the use of internal The main objective of