文档介绍：黄芩颗粒制粒工艺的研究
欧志辉兰慧阳敬张郴(通讯作者)
(红河卫生职业学院云南红河 661199)
【摘要】目的:优选黄芩颗粒的最佳制剂工艺。方法:按L9(34)进行考察的最佳成型工艺,即浸膏与辅料比,糖粉与可溶性粉比,乙醇浓度三个因素,以成品率及流动性为指标进行综合评价,筛选出最佳成型工艺参数。结果:以浸膏:辅料为1:2,可溶性粉:糖粉为1:2,乙醇浓度为80%为水提浸膏粉颗粒成型最佳条件。结论:本制粒工艺方法简便,稳定可控,可为开发成固体制剂提供了科学理论依据。
【关键词】黄芩颗粒正交试验制粒工艺
【中图分类号】+7 【文献标识码】A 【文章编号】1672-5085(2014)21-0080-02
【Abstract】 Objective:To select the optimum preparation technology for granules of Scutellaria :The optimum preparation technology examed by L9(34) refer to the synthetical process that proporation of powder and auxiliary materials,proporation of powdered sugar and dextrin,and adhesive used as detected factors and the mobility as detected indexs,which aim to find the best preparation of :The proportion of soluble starch and auxiliary materials was 1:2,proportion of dextrin and powdered sugar was 1:2,and optimum preparation technology of experiment,which were the best conditions of optimum preparation technology found in this :This preparation technology made in this research was convenient,steady and controllable,which provided solid preparation with scientific basis.
【Key words】granules of Scutellaria baicalensis orthogonal test granulating
technology
黄芩汤源于张仲景《伤寒论》太阳病篇,由黄芩、芍药、甘草、大枣四味药组。经临床使用具有清热止痢,和中止痛的功效[1]。用于治疗痢疾、急性胃炎、肠炎、小儿腹泻、消化道型病毒性感冒[2]。本文采用现代制药技术,将原方汤剂改制为服用携带方便,口感好,患者乐于服用的黄芩颗粒。采用L9(34)进行考察,对影