文档介绍：该【不明原因复发性流产患者绒毛组织中hsa-miR-125a-5p及其靶基因表达的研究 】是由【小泥巴】上传分享，文档一共【6】页，该文档可以免费在线阅读，需要了解更多关于【不明原因复发性流产患者绒毛组织中hsa-miR-125a-5p及其靶基因表达的研究 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?(?2)。?????Ч??б?(?±?)??????BMI/(kg/m2)????/dURSA?±±±ⅱ剟???±±±ⅱ剟?,)<?(?????????????p5-a125-miR-hsa????????、?MMP-2MMP-2mRNA???б?mRNA????????????(?<)URSA????????hsa-miR-125a-5p?(?3)。:..??????2023?1??32??1?·109·?????????hsa-miR-125a-5p?MMP-2mRNA???б?(?±?)????hsa-miR-125a-5pMMP-2mRNA??hsa-miR-125a-5p?MMP-2???????URSA?±#±*gい}殮弿垐拻?、?????????????MMP-2????±±}殮弿垐拻?????б??:????б?,*?<,#?<。???????????,????,?????????、????(?2A);URSA???、?????????hsa-miR-125a-5p?????miRanda????hsa-miR-125a-5??????????,????,???????p??,???:S≥140、ΔG≤-20kcal/mol。?????、????,??????????????,hsa-miR-125a-5p?щ????8?????(?2C);MMP-2????????????MMP-2?3’-???щ??(UTR)?????;????(?2B、2D);URSA?????????hsa-miR-125a-5p????MMP-2?3’-UTR,MMP-2?????????????[(±??MMP-2?????。??MMP-2?hsa-)vs.(±),?<)(?2B、2D,miR-125a-5p??????(?1)。?3)。A、B:???(B?A???????);C、D:URSA?(D?C???????);CT?????、SN?????。???????MMP-2??????(??????;A/C×200,B/D×400):..·110·??????2023?1??32??1?MMP-2?????。miR-125a?miR-125??????,????????????????miR-125a,?miR-125a-3p?miR-125a-5p。????,????、?????、???????????????????,??????、??、??????????[10-13]。??????????????????????????????miR-125a???。????б?,*?<????,miR-125a????????????、????????MMP-2?????б????????????[14-17]。??????????????,hsa-miR-??125a-5p?URSA??????(????)。Ч????URSA?????hsa-miR-125a-5p????????????,????????????????????,???????????????????????????????,???,??hsa-miR-125a-5p???URSA??????????????????????。?????????,???URSA??????。?,????????????????????[18]??????miR-125a???????????,????????????????????。??????????,????????,???????????????????,???????????。Ч???URSA?????????(MMPs)???????????、??hsa-miR-125a-5??????,???????[4]p????????,?p5-a125-miR-hsa??,???????2-MMP??。????????MMP-2???????????????????????MMP-2???,?????????????[5],???????????????,??????????,????????????,??????????????,?????????????,??????,???????,??????[6]。????,????、????、???????。????????????????????????,????????URSA??????[4,7-8]?MMP-2????。???hsa-miR-125a-5p???????????Ч??????,???????????、???MMP-2???????????????????、????????????????????,????????????,??????,?????,????;????URSA????????URSA???????????。?????,??????????、????、???????Ч??????????????????????????。URSA???????。MMP-2mRNA???????????????【????】?????,??URSA?????????????,?????,MMP-2??????.]J[??????????????.???,??,??]1[?????[9]?????/??????,2022,41:74-78.????????。[2]?ι?,???.?????????????[J].???MMP-2??????????,?????????????,2020,36:1033-1035.?????miRNA。miRNA???????щ[3]LiL,ZhangM,ChenW,-HOTAIRinhibition??RNA,??????????mRNA?3’-aggravatesoxidativestress-inducedH9c2cellsinjurythroughUTR??,??????????????,??suppressionofMMP2bymiR-125[J].ActaBiochimBiophysSin(Shanghai),2018,50:996-1006.??????????Ч。??????????[4]Cabral-PachecoGA,Garza-VelozI,Castruita-DelaRosaC,??MMP-2?hsa-miR-125a-5p????,hsa--125a-5p????MMP-2?3’-UTR,??inhibitorsinhumandiseases[J].IntJMolSci,2020,:..??????2023?1??32??1?·111·21:9739.[12]VoDT,KaranamNK,DingL,-125a-5pfunctions[5]SevalY,AkkoyunluG,DemirR,(MMP)-2and-9andtheirlocoregionalrecurrenceandpoorprognosisinheadandneckinhibitors(TIMP-1andTIMP-2)inthehumandeciduaduringcancer[J].Neoplasia,2019,21:849-[J].ActaHistochem,2004,106:353-362.[13]CaiZ,LiJ,ZhuangQ,-125a-5pameliorates[6]OnogiA,NaruseK,SadoT,-inducedpulmonaryarterialhypertensionbyofextravilloustrophoblastcellsthroughreductionofmatrixtargetingtheTGF-β1andIL-6/STAT3signalingpathwaysmetalloproteinase(MMP)-2activationintheearlyfirst[J].ExpMolMed,2018,50:1-[J].Placenta,2011,32:665-670.[14]AliA,HadlichF,AbbasMW,-mRNA[7]NissiR,Talvensaari-MattilaA,KotilaV,:acomprehensivematrixmetalloproteinaseMMP-9andMMP-2/TIMP-2downstreamanalysisofpotentialbiomarkers[J].IntJMolcomplexareassociatedwithspontaneousearlypregnancySci,2021,22:[J].ReprodBiolEndocrinol,2013,11:2.[15]BahiaW,SoltaniI,AbidiA,[8]WengD,HanT,DongJ,-2asmiRNAassociatedwithidiopathicrecurrentpregnancyloss:potentialbiomarkersinthedifferentialdiagnosisofanexploratorydataminingstudy[J].BMCMedGenomics,gestationaltrophoblasticdiseases[J].Medicine(Baltimore),2020,13:,101:e28768.[16]ManzoorU,PandithAA,AminI,[9]???.??????????????????????decreasedexpressionofmiR-125awithrespecttoitsvariant[D].??:????,:astudy[10]ZhangC,ZhaoY,WangQ,-inahighincidencezone[J].JClinMed,2022,11:-5pinhibitshepatocyteproliferationthroughtheSTAT3[17]JiaN,[J].IntJMolSci,2022,spontaneousabortionsandtheirdiagnosticpotential[J].Dis23:,2019,2019:7090767.[11]QuS,LiuZ,[18]??.??????????????э??miRNA??progressionbyimpairingmiR-125a-5pinhibitionofSFMBT1?????????[D].К?:К??????,[J].TherAdvChronicDis,2021,12:2040622320987348.[щ?:???]