文档介绍：Update in Radiotherapy for Non-Small Cell Lung Cancer
Cancer Institute & Hospital, Chinese Academy of Medical Sciences
Luhua Wang
Radiotherapy for NSCLC
Definitive radiotherapy for early stage non-small cell lung cancer
Definitive radiotherapy for locally advanced stage non-small cell lung cancer
Advanced technology in radiotherapy improved the treatment results
Normal tissue is properly protected
Definitive Radiotherapy for Early Stage NSCLC
the therapy provided a 98% rate of local control!
es After Stereotactic Lung Radiotherapy or Wedge Resection for Stage I Non–Small-Cell Lung Cancer
SRBT (n=55)
Wedge Resection (n=69)
P
Pulmonary Function(FEV-1)
(-)
(-)
NS
orbidity index
3
(1-4)
4
(3-6)
<
Age
74 (69-78)
78 (55-89)
<
Stage
T1-T2
T1-T2
NS
Greatest dimension
GTV: (1-)
Specimen: (-)
-
Positive mediastinal nodes
0 (PET, Mediastinoscopy)
0 (Surgery)
NS
Chemotherapy
16%
10%
NS
Grills et al: JCO 2010 doi: .
Authors
Pts
MFUT
RR or LR
DM
OS
CSS
Ginsberg, 1995
122
54
17
-
61
75
Landreneau, 1997
42
29
24
-
58
38*
60
24
16
-
65
38*
Sienel, 2007
49
54
16
-
-
67
Sienel, 2008
56
45
16
18
-
71
31
45
55
6
-
48
Keenan, 2004
54
27
11
9
62
74
El-Sherif, 2006
207
31
7
15
40
-
Lee, 2003
35
51
6
30
47
61
Voynov, 2005
110
41
4
8
18
-
Birdas, 2006
41
25
5
-
54
-
27
25
0
-
-
-
* local failure
14
25
14
-
-
-
es of Local Resection for Stage I Non–Small-Cell Lung Cancer
Authors
Pts
MFUT
RR or LR
DM
OS
CSS
Onisi, 2007
257
38
8-14
20
65
90
Negata, 2005
45
36
2
16-31
83
-
Uematsu, 2001
50
30
6
14
66
88
Zimmerman, 2006
68
17
12
16
51
73
Fakiris, 2009
70
50
12
13
43
82
RTOG, 0236
55
25
6
15
72
-
es After Stereotactic Lung Radiotherapy for Stage I Non–Small-Cell Lung Cancer
Mountain *
JCOG*
H*
Stage IA
Stage IB
67%
57%
80%
63%
74%
53