文档介绍：该【抑制低氧诱导因子-1α对PC12细胞L型钙通道表达的影响的综述报告 】是由【niuwk】上传分享，文档一共【2】页，该文档可以免费在线阅读，需要了解更多关于【抑制低氧诱导因子-1α对PC12细胞L型钙通道表达的影响的综述报告 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。抑制低氧诱导因子-1α对PC12细胞L型钙通道表达的影响的综述报告Lowoxygenlevelswithintissues(hypoxia),HypoxiaInducibleFactor-1α(HIF-1α),whichpromotestheexpressionofnumerousgenesinvolvedinangiogenesis,erythropoiesis,glucosemetabolism,,HIF-,manyneurologicalconditionssuchasstroke,Alzheimer'sdisease,andParkinson'sdiseasearecharacterizedbyhypoxia-,itisnecessarytounderstandthemechanismsofHIF-1αregulation,andspecifically,itseffectonL-,wewilldiscusstheroleofHIF-1αinregulatingtheexpressionofL--typecalciumchannelsareimportantforneurotransmitterrelease,neuronalactivity,andsignaltransduction,-typecalciumchannelsinPC12cells,andthatthisregulationisdependentonHIF--1αpromotestheexpressionofL-typecalciumchannelsinPC12cells,andthiseffectismediatedbythehypoxia-responseelement(HRE)presentinthepromoterregionofL--1αtoHREleadstotheactivationofL-ranscription,,recentstudieshavealsodemonstratedthatHIF-1αcanhaveanegativeeffectonL-,HIF-1αexpressioncanleadtotheinhibitionofL-typecalciumchannelexpressionthroughtheactivationofdownstreamsignalingpathwayssuchasthemammaliantargetofrapamycin(mTOR),whichisinvolvedintheregulationofcellmetabolism,growth,,theeffectsofHIF-1αonL-typecalciumchannelsinPC12cellscanalsobeinfluencedbyotherfactorssuchasreactiveoxygenspecies(ROS)andnitricoxide(NO).ROSandNOaregeneratedduringhypoxiaandhavebeenshowntoinhibitHIF-1αactivityandL--1αexpression,thusfurtherreducingL-,theregulationofL-typecalciumchannelsbyHIF--1αhasbothpositiveandnegativeeffectsonL-typecalciumchannelexpressioninPC12cells,,andtoidentifypotentialtherapeutictargetsforneurologicalconditionsassociatedwithhypoxia-induceddamage.