文档介绍:该【北京协和医学院基础医学院药理学系 】是由【小屁孩】上传分享,文档一共【42】页,该文档可以免费在线阅读,需要了解更多关于【北京协和医学院基础医学院药理学系 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。镇痛药Analgesics北京协和医学院基础医学院药理学系叶菜英2021/10/101镇痛药AnalgesicsS,eliminateoreasepainselectively,tolessenthenervousofpatients,theseagentsrelievepainwithoutproducingalossofconsciousness。。In1806,MorphinewasfirstisolatedfromthejuiceoftheopiumpoppybyGermanpharmacistFriedrichSertürner;Duringthe1950s,aseriesofmorphine-likepotentanalgesicsweresynthesized,suchaspethidine,methadone,etorphine,,anismsufferthenociceptivestimulus;Painisalsothebasisforthedoctorsdiagnosingdiseases。panyanxiety,dread,horror,fortandsoon,tocausethepatientsdisorder,evenshock。Acutepainthathasbeenmadeadefinitediagnosis,shoulduseanalgesicsimmediately;Butitisinadvisabletousenarcoticanalgesicswhenapainhasn`tbecertified,:chemicalconstitutionaffinityandintrinsicactivityAgonists:morphine,Pethidine,adanton……Antagonists:Naloxone,NaltrexonePartialagonist:Pentazocine,NalorphinePhysiologicaldisposition:takeorally,injection→passthroughthebloodbrainbarrier→hepaticmetabolism→renalexcretion2021/10/105HOHOONCH3吗啡morphine阿片(opium)生物碱类(opiatealkaloids)Morphine(1806,10%ofopiumtotalbase)Codeine(1832,methyl-morphine)Heroin(1874,acetomorphine,powerfuladdictivedrugs)PhenanthreneIsoquinolinePapaverine2021/10/106阿片生物碱类镇痛药阿片生物碱类***(poppy)2021/10/107FreshcapsuleofopiumpoppyCutcapsuleshowinglatexexudingfromcut2021/10/108镇痛药阿片生物碱类***(poppy)2021/10/109镇痛药阿片生物碱类含阿片生物碱类植物:***2021/10/1010