文档介绍：Hemorrhagic Fever with Renal Syndrome
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■ Definition
▲ Infectious diseases with natural source
▲ Pathogen: Hantan virus
▲ Characterized by fever, hemorrhage,
proteinuria, shock and acute renal
failure. Five phases in the typical cases
Febrile phase, Hypotensive (shock) phase,
Oliguric phase, Diuretic phase, Convalescent phase
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Epidemic Hemorrhagic Fever ( EHF)
Suggested name by WHO in 1982:
Hemorrhagic Fever with Renal Syndrome (HFRS)
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Hantan virus
▲ Member of the family of Bunyaviridae
▲ Feature of virus
Single-strand negative RNA virus
Circular or oval in shape
78~210 nm in diameter
Envelope proteins:glycoprotein1(G1)
glycoprotein2(G2)
Viral genome—RNA: L M S gene
■ Etiology
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Viral proteins
L--- Polymerase
M---Envelope protein G1 and G2
the membrane antigen
G2: contain neutrolization antigen
(ine antigen)
S---Nucleocapsid protein:
strong antigenicity and immunogenicity,
and plement binding antigen.
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▲ Resistance of virus
Low resistance:
Inactivated by acid (<pH ), ethanol, ether,
chloroform.
heat in 56ºC for 30min or 100ºC for 1min.
Be sensitive to alcohol
ultraviolet rays
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■ Epidemiology
of infection
▶
In our country:
Apodemus agrarius (黑线姬鼠)
Mus norvegicus (褐家鼠)
Apodemus sylvaticus (大林姬鼠)
Citellus undulatus (长尾黄鼠)
▶ Laboratory Rats
▶ Other animals: cats dogs rabbits
Patients:unimportant
Infected field rats, house rats
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Apodemus agrarius
黑线姬鼠
Mus norvegicus 褐家鼠
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