文档介绍：该【高血压与维生素D 】是由【落意心冢】上传分享，文档一共【36】页，该文档可以免费在线阅读，需要了解更多关于【高血压与维生素D 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。高血压与维生素D大量的流行病学研究发现,维生素D不足现象普遍存在。多数专家认为血清25(OH)D<20μg/L为缺乏;20~30μg/L为不足;≥30μg/L为充足。据估计维生素D缺乏或不足可影响世界范围内约50%人口,全球有近10亿人维生素D缺乏或不足。%%,%。研究背景bio-radVitaminDhaslongbeenknowntobeimportantforbonehealthCholecalciferol(D3)Ergocalciferol(D2)?bio-radSynthesisandMetabolismofVitaminD1,25二羟维生素D3与其维生素D受体结合形成激素-受体复合物,再与细胞核的维生素D反应元件相结合,激活或抑制含有维生素D反应元件的基因约200,从而发挥其生物学作用。Prevalenceofinsufficient25(OH)Dlevels(<30ng/ml)by sexandrace/ethnicityacrossagegroups: ThirdNationalHealthandNutritionExaminationSurvey41%ofmenand53%?Darkerskincoloring(increasedmelaninblocksUVBsynthesisofvitD)?LivinginNorthernHemisphere(greaterdistancefromequator)-forthoselivingabove35degreeslatitude,littleornovitaminDcanbeproducedfromNovembertoFebruary?Loweraltitude,morecloudcovering,sunscreen,coveredmannerofdress?Winterseason?Obesity(fatcellssequestervitaminD)?Malabsorptionsyndromes?Olderage(decreasedabsorptionfromdiet,decreasedproductionfromskin)?Kidneydisease(can'tmakeactivatedform)bio-radCHDdeathratesarehigerincountriesofincreasedgeographiclatitudeswhereaverageserumvitaminDarelowestbio-radmendations?mendeddailyallowance—200IU/dayforages1-50—400IU/dayforages51-70—600IU/dayforthose>70years—Maximumdailyallowance2000IU/day?mendeddailyallowance—600IU/dayforages1-70—800IU/dayforthose≥71—Maximumdailyallowance4000IU/day?2019update:Bloodlevels≥20ng/mlareprobablyadequatebio-radMeta-analysisofdataonall-causemortalityin18randomizedcontrolledtrials(includingWHI)withvitaminDSupplementation