文档介绍：该【LR7激动剂imiquimod的研究进展 】是由【相惜】上传分享，文档一共【23】页，该文档可以免费在线阅读，需要了解更多关于【LR7激动剂imiquimod的研究进展 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。Imiquimod--aTLR7agonistXiaochenYu20211021整理pptIntroductionImiquimodwasthefirstsmallmoleculeapprovedfortopicaluseinhumansthatwasshowntoactthroughtheToll-likereceptor(TLR)(pDC),,thisactivationresultsinsecretionofcytokinesincludinginterferon-α(IFN-α)andothers,upregulationofcostimulatorymoleculeexpressionandmaturationand/-viralactivityinpigsinfectedwithherpessimplexvirus,,(S-28463),imiquimod(S-26308).Humanperipheralbloodmononuclearcells(PBMC)整理pptMo-DC,ells(DC)derivedfrommonocytes,ells(pDC)整理pptImiquimod'sproapoptoticeffectinvitroImiquimodinhibitscellproliferationinprostatecancercelllines.〔detectedbyMTT〕整理pptImiquimodinducesapoptosisbyimiquimoddose-dependentandbypassofmitochondria-dependentinprostatecancercells整理pptATLR7inhibitorchloroquinedoesnotrestorethegrowthinhibitionbyimiquimodResults:ImiquimodinducedapoptosiswasindependentlyofTLR7andMyD88整理pptImiquimodinhibitsinvivogrowthofprostatecancerinmice整理ppt