文档介绍：anic Lab Experiments
anic Lab Experiments
● Technique 1. Identification Of pounds
● Technique 2. Flash Chromatography.
● Technique 3. Advanced Chemical Information Technology
● Technique 4. Preparative Vacuum Sublimation
● Technique 5. Advanced Molecular Modelling
● Technique 6. Reactions In Liquid Ammonia
● Technique 7. Vacuum Line Technique And Anaerobic Handling
● Technique 8. Reaction In A Pressure Bottle
● Technique 9. Advanced NMR Spectroscopy And 3D Interpretation
● Technique 11. Reactions Of Octal-2-Ones
● Technique 12. Catalytic Hydrogenation At Atmospheric Pressure
● Technique 15. Reactions In Liquid Ammonia
● Technique 16. Reductions With Lithium Aluminium Hydride
● Technique 18. Ozonolysis Of An Olefin
● Technique 19. Photochemistry Of Santonin
● Technique 20. Multi-Stage Syntheses
Copyright (c) ICSTM Chemistry Department, 1994.
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A1: ADVANCED IDENTIFICATIONS
Attempt to identify pound A and the natural product N.
Warning: Care must be exercised when handling and working with the 'unknown' compounds. As
a sensible precaution, assume them to be hazardous (many are) and avoid any skin contact,
inhalation of vapour or ingestion.
Compound A
i. Purify the material by distillation and/or recrystallisation. Record the . or, if liquid, the . and the
refractive index.
ii. Record the ., . and . spectra.
iii. Submit a sample of your pound for microanalysis. The submission forms are available at
the service counter. Completed forms, to which a small polytop sample vial containing a few mgs. of
your unknown A is attached, should be handed in via Nick Davies. The form will be returned to you
(after 1-2 weeks) with the correct position figures and the molecular weight inserted. You
will be assessed upon the accuracy of your results.
iv. Analyse the physical, spectral and microanalytical data in order to arrive at a structure for