文档介绍：现代生物医学进展 gress in Modern Biomedicine ·371 ·
前列腺癌内分泌治疗现状
杨翌王毅秦国庆李建军魏建华钱坤蒋鸿涛周浩
(南华大学附属第二医院泌尿外科湖南衡阳 421001)
摘要:前列腺癌(prostate cancer PC)是欧美国家男性发病率最高的恶性肿瘤,近年来其在我国的发病率也逐年升高。雄激素在 PC
的发生、发展过程中扮演着重要的角色,所以内分泌治疗一直是前列腺癌研究领域的重点,但是其可能诱发激素非依赖型 PC 这
也是临床医学面临的一大问题。本文就前列腺癌内分泌治疗的分类、作用机制、用药策略及临床效果等作一综述。
关键词:前列腺癌;激素抵抗;激素依赖;内分泌治疗
中图分类号: 文献标识码:A 文章编号:1673-6273(2011)02-371-04
The status of endocrine therapy on prostate cancer
YNAG Yi, WANG Yi, QIN Guo-qing, LI Jian-jun, WEI Jian-hua, QIAN Kun, JIANG Hong-tao, ZHOU Hao
(Department of Urology, The Second Affiliated Hospital of University of South China, Hengyang 421001, China)
ABSTRACT: Prostate cancer (PC)is the mon malignancy of male in Europe and American. The incidence increased in
recent years in our country. Steroid hormones play an important role in occurrence and development of prostate cancer, so endocrine therapy
for prostate cancer has been the focus in this field. It may induce the hormone refractory prostate cancer, which is one of the major difficul-
ties of clinical medicine. Classification, mechanism, administration strategy and clinical effects of endocrine therapy on prostate cancer
are reviewed in this article.
Key words: prostate cancer;hormone refractory;hormone dependent;endocrine therapy
Chinese Library Classification: R 737. 25 Document code: A
Article ID:1673-6273(2011)02-