文档介绍：29. A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis
By Shijiang He, Bo Song, Di Li, Changfeng Zhu, Wenpeng Qi, Yanqin Wen,
Lihua Wang, Shiping Song, Haiping Fang,* and Chunhai Fan*
Coupling nanomaterials with biomolecular recognition events represents a new direction in nanotechnology toward the development of novel molecular diagnostic tools. Here a graphene oxide (GO)-based multicolor fluorescent DNA nanoprobe that allows rapid, sensitive, and selective detection of DNA targets in homogeneous solution by exploiting interactions between GO and DNA molecules is reported. Because of the extraordinarily high quenching efficiency of GO, the fluorescent ssDNA probe exhibits minimal background fluorescence, while strong emission is observed when it forms a double helix with the specific targets, leading to a high signal-to-background ratio.
随着纳米科技领域的发展,研究纳米材料与生物分子相互作用的过程引领了纳米科技领域的一个新的研究方向,并且向着更加新颖的分子诊断工具方面发展。本文报道了一种基于多色荧光DNA探针的氧化石墨烯,并利用氧化石墨烯与DNA的相互作用,实现了在均相中快速、灵敏和具有选择性的检测目标DNA。因为氧化石墨烯具有非常高的淬灭效率,所以单链DNA荧光探针表现出最低的荧光背景,然而当与目标DNA形成双链结构时,可以看到很强的荧光发射,从而导致了高的信背比。
30. Noncovalent Assembly of Carbon Nanotubes and Single-Stranded DNA: An Effective Sensing
Platform for Probing Biomolecular Interactions
Ronghua Yang,†,‡ Zhiwen Tang,† Jilin Yan,† Huaizhi Kang,† Youngmi Kim,† Zhi Zhu,† and
Weihong Tan*,†
In this paper, we report the assembly of single-walle