文档介绍：该【SOX2在人胚胎干细胞及神经祖细胞中的功能及机制研究 】是由【niuwk】上传分享，文档一共【3】页，该文档可以免费在线阅读，需要了解更多关于【SOX2在人胚胎干细胞及神经祖细胞中的功能及机制研究 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。SOX2在人胚胎干细胞及神经祖细胞中的功能及机制研究Title:FunctionalandMechanisticStudiesofSOX2inHumanEmbryonicStemCellsandNeuralProgenitorCellsAbstract:SOX2,amemberoftheSOX(SRY-relatedHMG-box)transcriptionfactorfamily,(hESCs)andneuralprogenitorcells(NPCs).IthighlightstheimportanceofSOX2inthesecelltypes,emphasizingitsroleinmaintainingself-renewalandpluripotencyinhESCs,,thisreviewdiscussestheunderlyingmolecularmechanismsbywhichSOX2exertsitseffects,,:SOX2isakeytranscriptionfactorthatishighlyexpressedinearlyembryogenesisandplaysacriticalroleinthemaintenanceofpluripotencyandself-:-associatedtranscriptionfactors,suchasOCT4andNANOG,workthatregulatestheexpressionofgenesinvolvedinself-,SOX2isinvolvedintheregulationofcellcycleprogressionandapoptosisinhESCs,furthercontributingtotheirself--elltypes,:Duringneuraldevelopment,,gliogenesis,,,,,SOX2regulatesthebalancebetweenself-,:,knownasSOX2enhancers,,suchashistoneacetyltransferasesanddemethylases,,suchasPOU5F1andBRN2,,includingBMP,FGF,andWnt,:DuetoitscrucialroleinthemaintenanceofpluripotencyinhESCsandneuraldevelopment,(iPSCs),:Inconclusion,SOX2isakeytranscriptionfactorinhESCsandNPCs,,,offeringopportunitiesforthedevelopmentofnoveltherapeuticstrategiestargetingneurodegenerativediseasesandneuralinjuries.