文档介绍：脑白质疏松相关危险因素的回归分析
华中科技大学同济医学院附属同济医院神经内科硕士研究生:杨斐斐指导教师:王伟教授
中文摘要
目的探讨不同严重程度脑白质疏松(Leukoaraiosis,LA)的相关危险因素。方法连续筛选 2013 年 4 月至 2013 年 12 月同济医院神经内科住院并行头部 MRI 检查的病人,排除脑出血、脑梗塞、脑积水及各种特异性白质脑病等疾病后,将所得病例按照脑白质疏松诊断标准分为脑白质疏松组(LA 组)和无脑白质疏松组(无 LA 组),依据影像学评分(Fazekas 评分)将脑白质疏松病例按严重程度
分为轻度 LA 组和中重度 LA 组,收集患者临床资料,以白质病变等级为因变量, 各种可能的危险因素(包括年龄、性别、高血压病、糖尿病等)为自变量,进行 Logistic 回归分析。
结果共筛选出病例 352 例,其中轻度 LA 组 119 例,中重度 LA 组 119 例,无 LA 组 114 例。轻度 LA 组多因素回归分析有统计学意义的变量包括年龄、高密度脂蛋白偏低(p<,OR>1)。中重度 LA 组多因素回归分析有统计学意义的变量包括年龄、高血压病、糖尿病(p<,OR>1)。
结论年龄、高密度脂蛋白偏低是轻度脑白质疏松的独立危险因素。年龄、高血压病、糖尿病是中重度脑白质疏松的独立危险因素。
关键词脑白质疏松(LA);危险因素;回归分析
Regression analysis of relative risk factors for leukoaraiosis
Department of Neurology,Tong ji Hospital,
Tong ji Medical College,Hua Zhong University of Science and Technology Postgraduate Candidate:Yang feifei
Tutor: wei
Abstract
Objective To investigate the relative risk factors for leukoaraiosis of different grades. Methods Inpatients from to in Tong ji Hospital was screaned consecutively for cases undergone head MRI scanning and without cerebral infarction, intracerebral hemorrhage, hydrocephalus ,specific leukoencephalopathy and other serious systematic disease .Individuals enrolled in our study was divided into two groups ( leukoaraiosis and without leukoaraiosis) according to diagnostic criteria for leukoaraiosis. Patients in the group of leukoaraiosis were further divided into mild leukoaraiosis group ,moderate and severe leukoaraiosis group according to the Fazekas collected their clinical data and used logistic regression to analyze relative risk factors ,including age,gender, hypertension,diabetes ect.
Results A total of 352 cases enrolled was devided into three groups, mild leukoaraiosis(n=119),moderate and severe leukoaraiosis(n=119),and the group without leukoaraiosis(n=114). Regression analysis indicated that age,low high-density
lipoprotein cholesterol were related to mild leukoaraiosis(P< , OR>1)an