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Annual Work Summary Report
北京市神经外科研究所
01
Star markers:
MGMT
IDH1
EGFR
1p/19q
TP53
Ki-67
PTEN
MIB-1
Others
Types
02
Common imaging:
T1/T2
T1+
FLAIR
CBV
DTI/DWI
DCE-MR
MRS
PET
SPECT
03
单击添加内容标题
Contents
Star markers and Common imaging
IDH1
1p/19q
EGFR
P53
MGMT
T1/T2
Lai,et al 2011
, J. A.,et al 2012
, Philippe,et al 2010
, Philippe,et al 2010
JF,et al 2004
JW,et al 2011
, Maximilian,et al 2008
MS, et al 2011
, Ketao，et al 2015
, Y Y,et al 2014
, Y Y,et al 2015
JA,et al 2012
L,et al 2013
, Sung Soo,et al 2014
FLAIR
BM,et al 2013
, Philippe,et al 2010
, W. B,et al 2012
, Philippe,et al 2010
BM,et al 2013
C,et al 2012
BM,et al 2013
T1+
Lai,et al 2011
BM,et al 2013
, Philippe,et al 2010
, Philippe,et al 2010
BM,et al 2013
L,et al 2013
, Sung Soo,et al 2014
BM,et al 2013
DTI
, W L,et al 2014
, Sung Soo,et al 2014
DWI(ADC)
L,et al 2013
CBV
MRS
, W. B,et al 2012
DCE-MRI
, Sung Soo,et al 2014
PET
SPECT
Star markers and Common imaging
PTEN
MIB-1
Ki-67
Others
Types
T1/T2
N,et al 2012
, Olivier,et al 2014
, Xing,et al 2015
KM, et al 2013
FLAIR
C, et al 2012
, Olivier,et al 2014
T1+
DTI
, al 2014
DWI(ADC)
, A. K.,et al 2012
CBV
, A. K.,et al 2012
MRS
TG,et al 2015
DCE-MRI
PET
SPECT
Star markers and Common imaging
MGMT
1、水肿很少出现甚至不会出现在甲基化的肿瘤周围[4] 。
2、MGMT状态需要纹理特征分析才能够建立与MRI特征的联系[8、9] 。
3、MGMT与ADC呈正相关，ADC与PFS呈正相关[10]。
4、MGMT甲基化的肿瘤容易出现在左侧颞叶，而MGMT非甲基化的
肿瘤更倾向于长在右侧半球[3 ’] 。
5、MGMT非甲基化和EGFR扩增的肿瘤容易生长在右侧岛叶，丘脑，
颞叶并向侧脑室后部室管膜下区延伸[10’] 。
6、非甲基化的MGMT肿瘤在T1增强和T2/FLAIR像上比MGMT甲基化
的肿瘤强化面积大[3’] 。
. Ellingson. et al, AJNR,2013
MGMT promoter methylated tumors occur more frequently in the left temporal lobe
Probabilistic Radiographic Atlas of Glioblastoma Phenotypes
t-value
Prediction of methylguanine methyltransferase promoter methylation in glioblastoma using dynamic contrast-enhanced magnetic resonance and diffusion tensor imaging
SungSoo Ahn. et al, J Neurosurg ,2014
DCE-MRI permeability parameters: Ktrans may serve as a potential imaging biomarker to predict MGMT methylation status in glioblastoma.
Correlation of Apparent Diffusion Coefficient Values Measured by Diffusion MRI and MGMT Promoter Methylation Semiquantitatively Analyzed With MS-MLPA in Patients With Glioblastoma Multiforme
methylated MGMT
Un-methylated MGMT
T1W
ADC
The mean ADC revealed a positive relationship with MGMT promoter methylation ratio
Leonard Sunwoo et al, Journal MRI ,2012
IDH1突变的肿瘤好发于额叶而且肿瘤细胞临近脑室下区[3，3’]。
在DTI相中，利用部分异向分数和ADC可以在星形细胞胶质瘤
中监测IDH1 R132H的突变情况[5]。
1p/19q均表现为阴性[6]。
用标准的MRI特征就可预测IDH1的表达状态[4]。
随着年龄上升，IDH1突变减少，肿瘤更容易长在岛叶并且
1
2
3
4
5
IDH1
Relationship between Tumor Enhancement,Edema,IDH1 Mutational Status,MGMTPromoter Methylation, and Survival in Glioblastoma
All IDH1 mutant tumors were non-contrast enhancing tumor positive, and most were located in the frontal lobe.
. Carrillo et al, AJNR ,2012