文档介绍：胸腔留置中心静脉导管并灌注博莱霉素与顺铂治疗肺癌恶性胸腔积液疗效观察论文
刘向群王淑玲施海桑纯利
【摘要】目的探讨应用中央静脉导管进行胸腔闭式引流的临床价值,并观察博来霉素、顺铂治疗恶性胸腔积液的疗效。方法 46例肺癌伴恶性胸腔积液患者随机分为2组,2组患者均经皮胸腔穿刺,钢丝引导置入中心静脉导管并固定,加一次性使用输液器作延长管,接水封瓶行闭式引流。博来霉素组(n=23)予胸腔注射博来霉素40~60 mg/次、顺铂组(n=23)予胸腔注射顺铂60~80 mg/次,共3次,每次间隔1周。 and cis-diaminodichloroplatin in the treatment of the patients onary neoplasm bined alignant pleural effusion by thoracic cavity perfusion drainage. Methods 46 patients onary neoplasm bined alignant pleural effusion ly divided into tbedded ycin 40-60 mg and in group B (n=23), injection of cis-diaminodichloroplatin 60-80 mg ed at an interval of a es. Results The effectiveness of treatment in both groups ycin and cis-diaminodichloropl groups inodichloroplatin group arroarked difference in the incidence of side effects betycin group and cis-diaminodichloroplatin group (% vs. %, P ). Conclusion The closed drainage of pleural cavity anipulate, inor trauma, no plaints,.freelycin and cis-diaminodichloroplatin onary neoplasm bined alignant pleural effusion, but precautions should be taken to prevent inhibition of bone marros; pleural effusion; central venous catheter; cis-diaminodichloroplatin; bleomycin
恶性胸腔积液是肺癌患者最常见的临床并发症之一,其特点是胸腔积液增长迅速与反复发作,可严重影响患者的呼吸循环功能,直接威胁患者的生命。对于恶性胸腔积液的治疗,除了全身化疗等措施外,胸腔局部置管引流并灌注药物是目前最常用且最为有效的方法。笔者自2004年1月—2008年6月采用艾贝尔一次性无菌中心静脉导管穿刺包(闭式引流专用)进行胸腔置管闭式引流胸腔积液,胸腔内注射博来霉素和顺铂控制肺癌恶性胸腔积液,取得了较