文档介绍：EB病毒 DNA与鼻咽癌治疗预后之相关联性 The relationship between EBV DNA and prognosis in nasopharyngeal carcinoma
苏彦烨
Outline
Introduction of nasopharynx
Introduction of nasopharyngeal carcinoma (NPC)
Related articles of EBV DNA and NPC prognosis
- EBV DNA level and NPC recurrence
- EBV DNA level and distant metastasis
- EBV DNA level and survival
- EBV DNA level and treatment response
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The nasopharynx (nasal part of the pharynx) is the uppermost part of the pharynx
It extends from the base of the skull to the upper surface of the soft palate
Nasopharynx
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Fossa of Rosenmuller
Nasopharynx
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Examination of Nasopharynx
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Nasopharyngoscope
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Fossa of Rosenmuller
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Nasopharyngeal Carcinoma (NPC)
Epidemiology ---
Common in southern regions of China, particularly in Guangdong, Fujian, Hong-kong and Taiwan
150 cases per 100,000 people in Guangdong, cases per 100,000 people in Taiwan, and ~ per 100,000 people in USA
NPC is seen primarily in middle-aged (45~55 y/o) persons in Asia, a high proportion of African cases appear in children
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Etiology ---
Cause ?? Not clear
EB virus - related to undifferentiated type
Gene - (HLA-A2, Aw19, BSin 2, B17, BW16)
Diet (salted vegetables, fish and meat - dimethylnitrosamines)
Environment smoking, nickel exposure, formaldehyde(甲醛)
Nasopharyngeal Carcinoma (NPC)
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