文档介绍：线粒体功能紊乱与胰岛素抵抗
马慧娟宋光耀
[摘要]胰岛素抵抗是 2型糖尿病的重要发病机制,而骨骼肌线粒体功能紊乱与胰岛素抵抗密
切相关, 遗传、环境、衰老以及氧化应激可以导致线粒体功能紊乱。胰岛素抵抗者伴有线粒体功能下
降,通过运动或减重等手段改善胰岛素敏感性的同时,线粒体功能也得以改善,其机制可能与线粒体
功能异常通过抑制胰岛素受体底物-l活性、干扰胰岛素信号转导系统有关。
胰岛素抵抗;线粒体功能;2型糖尿病
Mitochondrial disfunction and insulinresistance MA Hui-juan SONG Guang-yao Department ofEndo
crinology ,The GeneralHospital of Hebei,Shijiazhuang 050051,China
[Abstract] Insulin resistanceis theimportant pathogenesis of type 2diabetes,while skeletal muscle
mitochondrialdisfunction closelyis related with insulin resistance. icfactors,environmental
aging,and oxidative stress caninduce insulin resistancehavelndividnals insulin
al dysfunction. Exercise or weight loss canincrease andinsulinsensitivityimprovedysfunction. mitochondrial
The mechanism maybe relatedthatmitochondrial theofinhibitsinsulindysfunctionactivityreceptorto
substrate-1 signalingwithsubstrate-1insulin,interferesystem.
Insulinresistance;Mitochondrial function;Type 2mellitus diabetes
. j. -4157. .
河北省自然科学基金资助项目( C2008001293)
050051石家庄,河北省人民医院内分泌二科
3
in Enthe
Rev,2010,31:25-
@@[ 12] Holloszy muscle "mitochondrial deficiency"not does
mediate insulin J Nutr,2009,89:463S-
@@[13 ] Nair KS, BigelowML, AsmannYW,et Ind