文档介绍：慢性乙型肝炎肝损伤患者临床特征与e抗原的关系_临床医学论文
慢性乙型肝炎肝损伤患者临床特征与e抗原的关系_临床医学论文
【摘要】目的: 对轻度及中度肝损伤的e 抗原(Hepatitis B e antigen, HBeAg) 阳性慢性乙型肝炎(chronic hepatitis B, CHB)和e 抗原阴性CHB 患者的临床特征进行比较。方法: 对44例HBeAg阳性CHB和36例HBeAg阴性CHB进行病史询问,检测肝功能、血常规、血清乙型肝炎病毒(HBV)免疫学标志和HBV DNA,并进行腹部B超检查。结果: HBeAg阳性CHB组和HBeAg阴性CHB组在性别构成比例、HBV感染阳性家族史和肝脾肿大方面差异无显著意义(P>)。HBeAg阳性CHB组和HBeAg阴性CHB组平均年龄分别为(±)岁和(±)岁(P<);HBV感染年限≥%% (P<);HBV ±±(P<)。结论: 在2组患者肝功能、血常规等临床特征一致的情况下,HBeAg 阴性CHB患者有年龄偏大、感染年限较长和HBV DNA滴度较低的特点。
【关键词】肝炎e 抗原,乙型; 肝炎,乙型; 病例对照研究
[Abstract] Objective: pare the clinical features of chronic hepatitis B (CHB) between types of Hepatitis B e antigen (HBeAg) positive and HBeAg negative. Methods: Investigation on 44 CHB patients with positive HBeAg (HBe-P) and 36 CHB patients with negative HBeAg (HBe-N) were carried out including asking disease histories, checking liver function, testing blood routine, and detection of HBV immunological marks and HBV DNA. Results: No significant difference was found in sex, family history of HBV positive infection, or splenohepatomegalia between groups HBe-P and HBe-N, of which the average patient age were ± and ± (), the percent of patients with disease period longer than 5 years were % and % (), and the average HBV DNA titre logarithm were ± and ±