文档介绍：中药灌肠联合低分子肝素治疗溃疡性结肠炎临床疗效观察
【关键词】中药灌肠;低分子肝素;溃疡性结肠炎
Abstract Objective:To evaluate the clinical curative effect of ulcerative colitis treated by Chinese traditional medicine clyster bined olecule :Forty patients icolon mild and moderate ulcerative colitis ly. A group edicine l/d, once a day, clyster, B group ental group, 20 patients, Chinese traditional medicine l/d, once a day, clyster, bined olecule heparin 5 000 U/bid subcutaneous injection for 1 CRP and colonscope ental group ission rate of the experimental group CRP value ental group, even :The clinical effect of Chinese traditional medicine clyster bined olecule heparin is better than that of Chinese traditional medicine clyster alone for the patients icolon mild and moderate ulcerative colitis and longterm therapeutic effect is very good.
Key edicine clyster; loolecule heparin; ulcerative colitis
溃疡性结肠炎(ulcerative colitis, UC )是一种病因和发病机制尚未明确的慢性肠道炎症性疾病。欧美发达地区发病率高,我的日益提高,近年来发病率也有增高[1]。UC的治疗比较困难,有研究表明UC存在血液高凝状态及血小板激活[2]。中药灌肠常用来治疗溃疡性结肠炎,尤其是左半结肠炎。曾有报道用肝素治疗UC可缓解症状,可能与抑制血小板活化有关[3-5]。因此,应用肝素来治疗UC具有理论基础。
1 资料与方法
研究对象病例选择按1993年太原举办的全国慢性非感染性肠道疾病学术研讨会标准[6]及2000年全国炎症性肠病诊疗规范[7],选择40例轻中度左半结肠溃疡性结肠炎患者, 将研究对象随机分为两组, A组为对照组, B组为实验组。
实验分组及方法将研究对象随机分为两组:A组20例,男13例,女7例,年龄22~51岁,病程3个月~12年不等,给予中药灌肠,100 ml/天,日一次灌肠;B组20例,男11例,女9例,年龄19~66岁,病程2个月~10年不等,给予中药灌肠,100 ml/天,日一次灌肠,同时给予低分子肝素5 000 U/日