文档介绍：第三军医大学
硕士学位论文
BMP-2在大鼠喙侧迁移流的发育学表达及其对SVZa神经干细胞体
外分化调控的初步研究
姓名:刘建军
申请学位级别:硕士
专业:人体解剖与组织胚胎学
指导教师:姚忠祥
20040501
第三军医大学硕士学位论文
常用英文缩写一览表

英文缩写英文名称中文名称
bFGF Basic fibroblast growth factor 碱性成纤维细胞生长因子
BMP-2 Morphogenitic proteins-2 骨形成蛋白 2
BMPRs Morphogenitic proteins receptors 骨形成蛋白受体
GCL Granule cell layer 颗粒细胞层
EPL External plexiform layer 球周细胞层
BMPs Morphogenitic proteins 骨形成蛋白
CNS Central nervous system 中枢神经系统
DA Dopaminergic 多巴胺能
DMEM o’s modified eagle medium 改良的基础培养基
GABA Gamma-aminobutyric acid g-氨基丁酸
GFAP Glial acidic fibrillary protein 胶质细胞纤维蛋白
h Hour 小时
LV Lateral ventricle 侧脑室
M Mol 摩尔
min Minute 分钟
mRNA Messenger RNA 信使 RNA
Nestin Neuroepithelia stem cell protein 神经上皮干细胞蛋白
NF Neurofilament 神经元
NGF Nerve growth factor 神经生长因子
NSCs Neuron stem cells 神经干细胞
OB Olfactory bulb 嗅脑球
PBS Phosphate buffered saline 磷酸盐缓冲液
RMS Rostral migratory stream 喙侧迁移流
rpm Roll per minute 每分钟转数
Reverse transcription polymerase chain 逆转录多聚酶链反应
RT-PCR
reaction
Sec Second 秒
1
第三军医大学硕士学位论文
Smad Sam-mother against dpp Sam-mad 蛋白
SVZa Anterior subventricular zone, 室管膜前下区
TGF- Transforming growth factor- 转化生长因子
TH Tyroxine hydroxylase 酪氨酸羟化酶

2
第三军医大学硕士学位论文
The Expressions of BMP-2 in Rostral Migratory Stream of
Developing Rat Brain and its Effects on the Differentiation
and Regulations of SVZa Neural Stem Cells in vitro

Abstract

With the lucubrating studies on neural stem cells (NSCs), the anterior subventricular
zone (SVZa) as a special area where NSCs are concentrated has been focused by more and
more reseachers. NSCs derived from SVZa not only possess the characteristics of NSCs,
but also have their own features: 1) they will migrate form SVZa to olfactory bulb (OB)
along an especial routeway- the rostral migratory stream (RMS) after they are produced; 2)
they will maintain proliferating and the characters of neural progenitor; 3) they differentiate
into maturated neurons while migrating