文档介绍：HBV 宫内感染预测指标的探讨
作者:潘文涛,尹玉竹,谌小卫,周水生
单位:中山大学附属第三医院妇产科, 510060
【摘要】【目的】探讨HBsAg阳性孕妇的新生儿乙肝联合免疫前的HBV-M和HBV DNA预测HBV宫内感染的实用价值。【方法】对我院2006年6月至2008年2月间分娩的HBsAg阳性孕妇的420例婴儿,其中新生儿HBsAg或HBV DNA阳性为33例,HBsAg和HBV DNA双阳性共6例,对其满6月龄时进行随访,复查HBV-M以确诊HBV宫内感染。【结果】 %(4/420),新生儿HBsAg或HBV ,而HBsAg和HBV 。【结论】 HBsAg阳性孕妇的新生儿乙肝联合免疫前的HBsAg和HBV DNA双阳性对HBV宫内感染具有较准确的预测作用,可以作为HBV宫内感染的初步临床诊断。
【关键词】乙型肝炎病毒; 宫内感染; 预测
Prediction Indexes of Hepatitis B Virus Intrauterine Infection
PAN Wen-tao, YIN Yu-zhu, CHEN Xiao-wei, ZHOU Shui-sheng, LI Xiao-mao
(Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China)
Abstract: 【Objective】 To investigate the value of HBV-M and HBV DNA of newborns born to HBsAg-positive mother, which were tested bined immunization of hepatitis B. 【Method】 A total of 420 infants born to HBsAg-positive mothers delivered in Obstetric Department of the Third Affiliated Hospital of Sun Yat-Sen University from June 2006 to February 2008 were followed up at least 6 months and rechecked HBV-M to confirm the diagnosis of HBV intrauterine infection, which included 33 HBsAg or HBV DNA positive newborn babies and 6 newborns with both HBsAg seropositive and HBV DNA seropositive. 【Result】 HBV intrauterine infection rate was %. Using newborn both HBsAg positive and HBV DNA positive as diagnostic criterion to diagnose HBV intrauterine infection, the positive likelihood ratio was , while using newborn HBsAg positive or HBV DNA positive as diagnostic criterion, it was . 【Conclusion】 Newborn both HBsAg positive and HBV DNA positive obtained bined immunization of hepatitis B may predict HBV intrauterine infection, and it may pla
y as a clinical index of preliminary diagnosis of HBV intrauterine infection.
Key words: hepatitis virus B; intrauterine infection; prediction
[J SUN Yat-sen Univ(Med Sci),2010,31(1):110-113]
既往国内以新生儿外周血乙型肝炎病毒表面抗原(Hepatitis B su