文档介绍：Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. PMID: 23580197
Ben Laufer
PI: Shiva M. Singh
Contributors: Katherine Mantha, Morgan L. Kleiber, Eric J. Diehl, Sean . Addison
Institution: Western University (formerly University of Western Ontario)
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Above and Beyond the Genome
e to The Post-Genomics Era
We’ve sequenced the human genome
It can now be done for only a few thousand dollars!
We can sequence thousands of human genomes!
Individual people can now go see their sequence!
The benefits we’ve seen are…
Is this it?
Shouldn’t cracking the code of life give us more breakthroughs than we can dream of?
Can 4 base pairs really code plex life?
What’s missing?
What treasure is left?
, Alper Uzun, PhD.
“A mitotically (or meiotically) inheritable change in gene expression, independent of an alteration in DNA sequence”
Berger et al. (2009) Genes Dev.
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The Solution to the Post Genomics Era: ics
ic Mechanisms (Macmillan Publishers Ltd: Nature 441: 143-145. 11 May 2006)
A Few ic Mechanisms of Interest
Histone Modifications
MicroRNA
DNA Cytosine Methylation
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Images from mons
Redefining the Central Dogma
Saletore et al. Genome Biology 2012, 13:175
ic Mechanisms
Histone Modifications
MicroRNA
DNA Cytosine Methylation
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ic Mechanisms
Histone Modifications
MicroRNA
DNA Cytosine Methylation
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