文档介绍：Inflammation
Guo Chenghao, ./.;
Professor
Shandong University
Introduction:
“Inflame”– to set fire.
Inflammation is the response of living tissues to cellular involves both innate and adaptive immune mechnisms
Is a protective response.
Serves to bring defense & healing mechanisms to the site of injury.
Classical Signs of Inflammation
Redness – Hyperaemia.
Warm – Hyperaemia.
Pain – Nerve, Chemical mediators ,K
Swelling – Exudation
Loss of Function: …
Fever and leukocytosis systemically
Inflammation Classical Signs
Pathogens of inflammation
Physical, chemical, autoimmune, ic,
monly is biological,
Such as bacteria, virus, rickettsia, fungi, leptospira, protozoa, and parasites.
Anything that cause tissue injury, that initiates inflammation.
Classification of inflammation
Pathological
Alteration
Exudation
Proliferation
Clinical
Peracute h ~ days
Acute days ~ weeks
Subacute months
Chronic more than half of a year
Alteration
Cellular/tissue injury changes(degeneration and necrosis) in inflammation area.
(1) Parenchyma(Business) cells: hydropic change;fatty change;coagulative necrosis;liquefative necrosis
(2) Interstitial : mucoid degeneration; fibrinoid necrosis
Exudation
Inflammatory process of edema fluid with high rich proteins, inflammatory cells, and fibrinogen rate through blood vessel wall to the interstitial tissue space, body cavity, and the surfaces of mucosa as well as the skin of the body.
Exudate Edema fluid with a high protein concentration (specific gravity >) that often contains ponents, such as leukocytes, fibrin, etc.
Proliferation
Under the stimulation of inflamatory factors , necrotic cell debris and some phycical /chemical factors, the numbers of local macrophage , endothelium and fibroblast increased
Epithelium and parenchyma cell proliferation surrounded inflammatory location