文档介绍：< ); g/kg to g/kg dose pared with model group, HE dyeing
histopathologic grading Masson group scores were significantly lower (p<).
Conclusion: Tiange capsule on papain induced osteoarthritis in rats model has obvious therapeutic effect, its mechanism may be related to regulate MMP-3、TIMP-1、MMP-3/TIMP-1 value.
Jin Tiange capsule on rats by Hulth surgery to osteoarthritis model has obvious therapeutic effect, its mechanism may be related to regulating the NO,MDA,SOD,IL-1β,TGF-β1 value.
Jin Tiange capsule on two different models of osteoarthritis in rats has the treatment function. Tip might be in a variety of reasons caused by osteoarthritis have a therapeutic effect.
Key words: Jin Tiange capsule; Osteoarthritis; Articular cartilage;Rat
Author:HOU Xiao-li Tutor: XU Ai-ying
目 录
引 言................................................................ 1
第一部分 理论研究................................................... 2
1 现代医学对骨关节炎的认识与研究进展.................................... 2
2 中医医家对骨关节炎的认识与研究进展.................................... 4
3 关于金天格胶囊的研究概况.............................................. 6
第二部分 实验研究................................................... 8
实验一:金天格胶囊对木瓜蛋白酶诱导的 OA 大鼠模型的影响 8
1 实验材料............................................................ 8
2 预实验方法与结果.................................................... 9
3 实验方法........................................................... 10
4 实验结果........................................................... 12
实验二:金天格胶囊对 Hulth 手术致 OA 大鼠模型的影响 17
1 实验材料........................................................... 17
2 预实验方法与结果................................................... 18
3 实验方法........................................................... 19
4 实验结果........................................................... 24
讨论.................................................................. 28
1 对动物模型的讨论................................................... 28
2 对实验结果的讨论..............................