文档介绍：肿瘤标忐物CA242、CAl9-9、CAl25对胰腺癌的诊断作}『j研究中文摘要
中文摘要 t F 56553 s
目的研究及比较肿瘤标志物CA242、CAl9—9、CAl25对胰腺癌的诊
断作用。
方法测定我院2002年1 -2003年3月住院及门诊胰腺癌病人42 例,良性胰腺疾病、肝胆疾病及其它恶性肿瘤74例,正常对照36例的CA242 (IRMA法)、CAl25<CLIA法)血清水平。
结果在胰腺癌组病人中,CA242及CAl919血清值与其它各组及正常对照组比较有显著升高(p<),而其它各组与正常对照组之间无显著差异(P>),CAl25血清水平在胰腺癌组病人中有显著升高(P<),但在肝癌等恶性肿瘤组及胰腺良性病变组亦有明显升高且与胰腺癌组相比差别无显著性(P>)。CA242、CAl9。9及CAl25血清水平在胰腺癌不可手术切除组明显高于可手术切除组(P<)。 %,%,%;特异性方面CA242为
%,CAl9。9为72。973%,%,CA242在特异度方露显著高于CAl9—9、CAl25(P<),敏感性方面CA242、(》)。以不同组合方式联检CA242、CAl9—9、CAl25,敏感性;+CAl25 %、 CA242+CAl25 %、
CAl9-9+CA242 %、CAl9—9+CA242+CAl25 %特异性;系列实
+CAl25 87。838%、CA242+CAl25 %、+CA242
%、CAl9—9+CA242+CAt25 %。系列实验时,+CA242 %,CAl9—9+CA242+%有显著差
肿癌标志物CA242、CAl 9-9、CAl25对胰腺癌的诊断作用研究
异(P<)。
结论胰腺癌肿瘤标志物CA242、,CA242虽敏感性不沈CAl9。9优异,但其特异性显著好于CAl9—9, 单检CAl25对胰腺癌的诊断价值不丈。测定血清肿瘤标志物CAl9。9、CA242 对有赘予评价濮腺癌的手术可切除毪及预后。CAl9—9+CA242是优选的联检缀合方式,联捡CA242、CAl9-9耱提藏对胰艨癌的诊断效率。
关键词CA242、CAl9—9、CAl25簇黥瘗
作 者:万晓冬指导老师:李德春
lI
瓣臻轹岳糖CA242、CA|9—9、CAl25对簇艨癌的睁耨幸摹挪秘究 英文摘嫠
Abstract
objective To investigate the diagnostic Value of serUlTl levels of CA242、
CA】9—9 and CAl25 in Pancreatic cancer
Methods In our hospital,from January 2000 to March 2003,total plasma levels of CA242 were measured in珏凇methods and 、
CAl25 were measured in CLIA methods in blood samples from 36 healthy donors and 1 16 patients with PC、benign pancreatic lesions、 benign hepatobiliary diseases and other malignancies,their diagnostic value were assessed.
Results There were no significant differences in serum CA242 and CAl 9—9 levels between healthy donors and all other patients whereas patients with PC had significantly elevated CA242 and CAl9-9 serum CAl25 ,which in patients with PC were significantly elevated,also,were both elevated in patients诚氇 b