文档介绍：颅内感染患者脑脊液和血清中IFN
【摘要】目的观察病毒性脑膜脑炎、化脓性脑膜脑炎患者急性期和恢复期脑脊液和血清中的IFN-γ、IL-10和S-100B蛋白含量变化并探讨其意义。方法 32例病毒性脑膜脑炎患者(病脑组)和28例化脓性脑膜脑炎患者(化脑组)作为观察组,30例与观察组相匹配的紧张性头痛或神经症患者及健康体检者作为对照组,采用双抗体夹心ELISA法分别检测其脑脊液和血清中IFN-γ、IL-10和S-100B蛋白的浓度。结果病脑组和化脑组患者急性期脑脊液和血清IFN-γ、IL-10、S-100B蛋白水平显著高于恢复期和对照组(P<),急性期病脑组患者脑脊液和血清IFN-γ水平显著高于化脑组(P<),急性期化脑组患者脑脊液和血清IL-10、S-100B蛋白水平显著高于病脑组(P<);急性期脑脊液和血清IFN-γ/IL-10 比值关系为:病脑组>对照组>化脑组(P<);急性期昏迷患者血清和脑脊液中S-100B蛋白浓度显著高于无昏迷患者(P<)。结论 IFN-γ、IL-10、S-100B蛋白参与了中枢神经系统感染性疾病的病理过程,脑脊液或血清中的S-100B蛋白浓度反映了神经胶质细胞的损害程度,脑脊液和血清中IFN-γ、IL-10及IFN-γ/IL-10 比值的测定有助于病毒性脑炎与化脓性脑膜炎的鉴别诊断。
【关键词】颅内感染;后脊液;白细胞介素-10;γ-干扰素; S-100B蛋白
Abstract: Objective To observe changes of IFN-γ,IL-10 and S-100B protein level in cerebrospinal fluid and serum in patients eningoencephalitis and suppurative meningoencephalitis in the acute and recovery phase,and to explore its 32 cases eningoencephalitis (VMgroup) and 28 cases eningoencephalitis (PM group) inaters ed by statistical The acute phase had significantly higher concentration of IFN-γ,IL-10 and S-100B protein in cerebrospinal fluid and serum than the recovery phase and control group had (P<).VM group had significantly higher concentration of IFN-γ in cerebrospinal fluid and serum than PM group had in the acute phase (P<).PM group had significantly higher concentration of IL-10 and S-100B protein