文档介绍：,
·1404· Journal of Clinical and Experimental Medicine Vol. 10 No. 18 Sep. 2011
病毒感染患者抗病毒治疗前后淋巴细胞亚群的变化及意义论著
田瑛张娟王红* 首都医科大学附属北京友谊医院感染暨急救医学科北京 100050
【摘要】目的通过对病毒感染急性期患者抗病毒治疗前后外周血淋巴细胞亚群的检测,比较其差异,初步探讨
病毒感染患者细胞免疫功能的变化及抗病毒治疗对宿主细胞免疫功能的影响。方法收集 2010 ~ 2011 年感染科收治
的病毒感染急性期患者 20 例,使用流式细胞仪检测其外周血 T 细胞亚群,与正常对照组比较,分析其差异。选取其中
10 例患者,于抗病毒治疗 1 周后再次检测外周血 T 细胞亚群,比较治疗前后变化并分析其意义。结果与正常对照相
比,病毒感染患者外周血 B 细胞减少,T 细胞、CD8 + T 及 CD8 + CD38 + T 细胞比率及计数升高。抗病毒治疗 1 周后,患者
白细胞、CD8 + CD38 + T 细胞计数降低。结论病毒感染急性期患者体内存在 T 淋巴细胞亚群失衡和细胞免疫功能紊
乱,而早期抗病毒治疗有助于减轻病毒感染导致的异常免疫激活和免疫损伤。
【关键词】病毒感染淋巴细胞亚群抗病毒治疗免疫损伤
The change and significance of peripheral blood lymphocyte subsets after antiviral therapy in patients with acute virus infection. TIAN
Ying,ZHANG Juan,WANG Hong* . Department of Infectious Diseases,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,
China.
【Abstract】 Objective To investigate the change of host's cellular immunity and the effect of antiviral therapy on host's cellular immunity
in patients with acute virus infection. Methods Flow cytometry was used to detect the peripheral blood lymphocyte subsets in 20 patients with
acute virus infection and 20 health blood donors. And re - examine of peripheral blood lymphocyte subsets was performed in 10 patients after anti-
viral therapy. pared with normal controls,the count and the proportion of lymphocytes,T - lympho