文档介绍：磁化支架防治犬PTCA术后冠状动脉再狭窄
作者:吕安林贾国良郭文怡杨省利王小燕胡涛
【关键词】冠状动脉疾病
关键词: 冠状动脉疾病;血管成形术,经腔,经皮冠状动脉;磁化支架;冠状血管/损伤
摘要:目的探讨磁化支架对(PTCA,Percutaneous trans-luminal coronary angioplasty)术后冠状动脉再狭窄的防治作用. 方法 20只健康杂种犬,超大球囊反复扩张损伤靶血管(前降支或旋支中段)制备PTCA术后冠状动脉狭窄模型(大于50%)后随机分成对照组和实验组各10只,对照组靶血管置入普通Palmaz支架,、后不用抗血小板药和抗凝药,术后6mo冠状动脉造影并处死犬,切取靶血管3cm进行组织病理学检查. 结果冠状动脉造影示冠状动脉再狭窄率对照组30%,实验组0;组织病理学检查靶血管平均内膜厚度[对照组(±)mm,实验组(±)mm]有显著差异,P<. 结论磁化支架对犬PTCA术后冠状动脉再狭窄有显著的防治作用.
Keywords:coronary disease;angioplasty,transluminal,per-cutaneous coronary;ic stent;coronary vessels/injury
Abstract:AIM To investigate the preventive effect of ic stent on coronary restenosis after percutaneous translu-minal coronary angioplasty(PTCA).METHODS Twenty dogs were randomly distributed to control and experimental groups,each mon Palmaz-stents in6-8seg-ments of left anterior descending or11-14segments of left circumflexus,were implanted into the control dogs and ic stents were implanted into the same parts of coronary arteries of the experimental the dogs did not take any antiplatelet and anticoagulant before and after the opera- later20dogs underwent coronary angiogra-phy,then put to death and3cm target vessel was taken from each dog for pathological Three dogs in the control were overtaken with more than50%restenosis,but no one in the experi