文档介绍：HBsAg(—)伴HBcAb(+)妇科肿瘤患者TP化疗方案化疗后乙肝病毒7600字
[摘要] 目的探讨HBsAg(-)伴HBcAb(+)妇科肿瘤患者行TP方案化疗后发生乙肝病毒再激活的肝功能损害情况。方法收集我院近7年收治的60例使用TP方案化疗的妇科肿瘤患者的临床资料,根据HBcAb结果不同分为实验组及对照组,分析其肝脏损害程度及乙肝病毒再激活情况。%(18/30),%(13/30),两组差异无统计学意义(P>);实验组肝功能损害Ⅰ度+Ⅱ度12例,Ⅲ度+Ⅳ度6例,对照组Ⅰ度+Ⅱ度12例,Ⅲ度+Ⅳ度1例,实验组肝功能损害程度更严重,两组差异有统计学意义(P<)。实验组4例胆红素升高,对照组2 例胆红素升高,两组差异无统计学意义(P>);实验组乙肝再激活1×103 Copies/mL1×105 Copies/mL 2例,对照组乙肝再激活0例,两组差异具有统计学意义(P<)。实验组22例(%)继续按期化疗,6例(20%)延期化疗,2例(%)终止化疗;对照组30例按期化疗,两组差异有统计学意义(P<)。结论 HBsAg(-)伴HBcAb(+)妇科肿瘤患者TP化疗严密观察肝功能,检测乙肝HBsDNA定量检测。
[关键词] 妇科肿瘤;乙型肝炎病毒;再激活;化疗
[中图分类号] [文献标识码] B [文章编号] 1673-9701(2016)12-0081-04
Clinical research on HBV reactivation after TP chemotherapy in patients ors ent of Tumor Medicine, Zhongshan Bo’ai Hospital in Guangdong Province, Zhongshan 528400, China
[Abstract] Objective To discuss the liver function impairment by HBV reactivation after TP chemotherapy in patients ors aterials of 60 patients ors after TP chemotherapy pairment and HBV reactivation. Results The rate of liver function impairment pairment, and 6 cases pairment es;103 Copies/mL105; otherapy, 6 cases(%) otherapy, and 2 cases(%) chemotherapy; otherapy, ors onitored during TP chemotherapy and HBsDNA should be detected. [Key or; Hepatitis B virus; Reactivation; Chemotherapy
化疗是妇科恶性肿瘤重要的治疗方法,可以杀灭隐匿的肿瘤细胞,防止转移和复发;对于复发性