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在肿瘤学方面有哪些好的杂志
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论文的主要结构
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肿瘤的分子信号转导
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+ genomic
instability
from Hanahan and Weinberg 2000
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Signal Transduction and Cancer
Lecture I: Growth Factors and Receptors
Outline:
What is Signal Transduction?
What are Growth Factors?
How do they contribute to normal ST?
How is this ST deregulated in Cancer?
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Lecture I: Growth Factors and Receptors
What is Signal Transduction?
Signal Transduction is the process by which a cell
converts an extracellular signal into a response.
Involved in:
Cell-munication
Cell’s response to environment
Intracellular homeostatsis- munication
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Generic Signalling Pathway
Signal
Receptor (sensor)
Transduction Cascade
Targets
Response
Altered Metabolism
Metabolic
Enzyme
Gene Regulator
Cytoskeletal Protein
Altered Gene Expression
Altered Cell Shape or Motility
Adapted from Molecular Biology of the Cell,(2002), 4th edition, Alberts et al.
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Components of Signalling
What can be the Signal?
External message to the cell
Peptides / Proteins- Growth Factors
Amino acid derivatives - epinephrine, histamine
Other small biomolecules - ATP
Steroids, prostaglandins
Gases - Nitric Oxide (NO)
Photons
Damaged DNA
Odorants, tastants
Signal = LIGAND
Ligand- A molecule that binds to a specific site on
another molecule, usually a protein, ie receptor
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Components of Signalling
What are Receptors?
Sensors, what the signal/ligand binds to initiate ST
Cell surface
Intracellular
Hydrophillic Ligand
Cell-Surface
Receptor
Plasma membrane
Hydrophobic
Ligand
Carrier Protein
Intrace