肾细胞癌治疗进展.ppt

文档介绍：肾细胞癌的治疗进展
肾细胞癌的危险因素分级
Memorial Sloan-Kettering Cancer Center ()预后分期系统
University of Califonia Los Angeles(UCLA)预后分期系统
Low KPS (< 80%)
low serum hemoglobin, 13 g/dL (男) or g/dL(女)
high corrected calcium > 10 mg/dL;
Motzer, R. J. et al. J Clin Oncol; 22:454-463 2004
Survival curves for patients treated before 1990 according to risk group
UCLA
Stratified 4202 patients (5YS)
局部:92%(低危) 67%(中危) 44%(高危)
转移:37% (低危) 23% (中危)15% (高危)
传统治疗
IL-2
IFN
chemotherapy
High dose IL-2
600,000 to 720,000 IU/kg of binant human IL-2 was administered by 15-minute infusion every 8 hours ×14 doses
There were 17 (7%) complete responses (CRs) and 20 (8%) partial responses (PRs).
In ICU , selected patients