核基质蛋白22、细胞角质素20和存活素在膀胱癌诊断和复发预测中的价值.pdf

文档介绍：第三军医大学
博士学位论文
核基质蛋白22、细胞角质素20和存活素在膀胱癌诊断和复发预
测中的价值
姓名:万江华
申请学位级别:博士
专业:外科学(泌尿外)
指导教师:靳风烁
20040501
第三军医大学博士学位论文
英文缩写一览表

英文缩写英文全称中文译名
BCG Bacillus Calmette-Guerin 卡介苗
Bp Base pairs 碱基对
plementary DNA 互补 DNA
CK Cytokeratin 细胞角质素
d Day 天
DEPC Diethyl pyrocarbonate 焦碳酸二乙酯
DAB Diaminobenzidine 二氨基联苯胺
DNA Deoxyribonucleic acid 脱氧核糖核酸
dNTP Deoxynucleoside triphosphate 脱氧核苷三磷酸
EB Ethidium bromide 溴化乙啶
ELISA Enzyme-linked immunosobent assay 酶联免疫吸附试验
h Hour 小时
HRP Horseradish peroxidase 辣根过氧化物酶
IAP Inhibitor of apoptosis 凋亡抑制蛋白
IFN Interferon 干扰素
IL-2 Interleukin–2 白细胞介素-2
Kb Kilobase pairs 千碱基对
Kda Kilodalton 千道尔顿
Min Minute 分钟
NED No evidence of disease 无疾病证据
NMP22 Nuclear matrix protein 22 核基质蛋白 22
NuMA nuclear mitotic apparatus protein 核有丝分裂器蛋白
OD Optical density 光密度
PBS Phosphate buffer saline 磷酸缓冲盐溶液
RBC Red blood cell 红细胞
Rnase Ribonuclease RNA 酶
1
第三军医大学博士学位论文
rpm Round per minute 每分钟转数
RT-PCR Reverse transcriptase-polymerase chain 逆转录聚合酶链式反应
reaction
SBC Superficial bladder cancer 浅表性膀胱癌
Sec Second 秒
TBE Tris/borate/ EDTA(buffer) Tris/硼酸/EDTA 电泳缓冲液
TCC Transitional cell carcinoma 移行细胞癌
Tris Trihydroxymethylaminomethane 三羟甲基氨基甲烷
TURBT Transurethral resection of bladder 经尿道膀胱肿瘤电切
Tumor
UC Urinary cytology 尿细胞学
2
第三军医大学博士学位论文
Nuclear matrix protein 22,cytokeratin 20 and survivin
as diagnostic and prognostic markers for bladder tumor


Abstract

Bladder carcinoma is the mon seen tumor in urinary than 90% of
bladder carcinoma is transitional cell carcinoma(TCC).More than 80% of TCC of the
bladder is superficial bladder carcinoma(SBC).Recurrence of TCC of the bladder is
than 50% to 90% of SBC recur within 5 years while 10% to 20% progress to
invasive disease. essful management depends on regular follow-up and early detection
of persistent or recurrent most accepted surveillance for patients is based
on cystoscopy,the reference diagnost