文档介绍：卡培他滨联合奥沙利铂治疗晚期结肠癌的疗效观察
作者:王运红作者单位:广东省深圳市龙岗区沙湾医院肛肠科,广东深圳
【摘要】目的:探讨卡培他滨联合奥沙利铂治疗晚期结肠癌的疗效。方法:将我2009年11月~2010年12月收治的60例结肠癌患者随机分为对照组和治疗组,每组30例。对照组给予卡培他滨单药治疗;治疗组采用卡培他滨联合奥沙利铂治疗。比较两组患者的临床疗效、生存时间、1年和2年生存率以及不良反应发生情况,并进行统计分析。结果:治疗组临床有效率和疾病控制率均明显高于对照组(P<);治疗组的生存时间、1年和2年生存率均高于对照组(P<);两组不良反应发生率比较差异无统计学意义(P>)。结论:培他滨联合奥沙利铂治疗结肠癌效果优于单一的卡培他滨治疗,值得推广应用。
【关键词】卡培他滨,奥沙利铂,结肠癌
[ABSTRACT] Objective: To discuss the effect bination therapy of capecitabine and oxaliplatin on advanced colorectal cancer (ACC). Methods: A total of 60 patients with ACC were randomly divided into control group and treatment group by half. The patients in control group were only given capecitabine while the treatment group received the treatment of capecitabine and oxaliplatin. The survival time, survival rate of 1 year and 2 year and incidence of adverse reactions pared between the two groups. Results: The clinical efficacy and control rate of the disease in the treatment group were significantly higher than that in the control group (P<); The survival time, survival rates of 1 year and 2 year in the treatment group were also higher than the control group (P<); there were no significant difference in the incidence of adverse reactions between the two groups (P> ). Conclusions: bination therapy of capecitabine and oxaliplatin is effective on treating ACC. It is worthy extensive application.
[KEY W