文档介绍：WARNING NOTICE: The experiments described in these materials are potentially hazardous and require a high level
ofsafety training, special facilities and equipment, and supervision by appropriate individuals. You bear the sole
responsibility, liability, and risk for the implementation of such safety procedures and measures. MIT shall have no
responsibility, liability, or risk for the content or implementation of any of the material presented. Legal Notices
. Extraction and Washing Guide
Overview:
This handout describes standard extraction and washing protocols that can be applied to
virtually any crude reaction mixture. Aqueous washings are done to remove water soluble
impurities anic products since normally pound that you desire will be dissolved in
anic layer.
Reference:
For an excellent discussion, read Zubrick pages 127–138.
Standard Aqueous Workup Protocol:
1) Pick anic solvent. Ether is the most popular because it can be removed easily on
the rotary evaporator, ethyl acetate also works well but is harder to remove, dichloromethane
is a poor choice and should be avoided, if possible, since it often forms nasty emulsions and
complicates matters because it is heavier than water.
2) Pick the size of your separatory (sep.) funnel. You will usually use 125 or 250-mL,
large scale reactions (1–10 g) can require 500-mL or 1-L