文档介绍：七叶皂苷钠在术后早期炎性肠梗阻治疗中的应用及其可能作用机制探讨
邓锋黄涛
[摘要]  目的  探讨七叶皂苷钠在术后早期炎性肠梗阻治疗中的临床应用特点及其作用机制。方法  回顾性分析我院2007年3月~2010年4月收治的47例术后早期炎性肠梗阻的病例资料,资料分两组:治疗组(27例)和对照组(20例)。两组均采用禁食、胃肠减压、生长抑素、肠外营养等支持基础疗法,治疗组另给予七叶皂苷钠。结果  治疗组经非手术治疗全部临床治愈(100%),无再手术病例,(7~18d);对照组经非手术治疗17例(85%)临床治愈,3例中转开腹手术,(9~23d)。结论  非手术保守治疗对术后早期炎性肠梗阻效果满意,应用七叶皂苷钠能够促进肠梗阻的再通,提高治愈率,减少治愈时间,减轻患者长期置管痛苦。七叶皂苷钠的作用机制可能是减轻肠壁水肿,减少肠道炎性渗出,促进肠道蠕动。
[关键词]  七叶皂苷钠;术后早期炎性肠梗阻;临床应用
[Abstract]  Objective  To explore the clinical application characteristics and mechanism of aescin in the treatment of early postoperative inflammatory ileus. Methods  The clinical data of 47cases of the early postoperative inflammatory small bowel obstruction,our hospital admitted in to April 2010 were analyzed retrospectively. The patients were  divided into two groups: treatment group (27cases) and control group (20 cases). All patients were fasting,gastrointestinal pression,somatostatin,parenteral nutrition support basic therapy,  Treatment group plus aescine sodium. Results  Treatment group were all clinical cure in non-surgical treatment(100%),no reoperation. The average healing time was (7~18d) 17cases  were clinical cured in control group(85%),3 cases were converted to open surgery. The average healing time was (9~23d). Conclusion  Non-surgical conservative treatment of early postoperative inflammatory ileus is satisfactory.